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Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
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Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
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Journal Article
Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
2017
Overview
Discovering a new cell transplantation approach for treating chronic renal insufficiency is a goal of many nephrologists. In vitro-cultured peripheral blood mononuclear cells (PBMCs) were reprogrammed into induced mesenchymal stem cells (iMSCs) by using natural inducing agents made in our laboratory. The stem cell phenotype of the iMSCs was then identified. Unilateral ureteral obstruction (UUO) was used to create an animal model of chronic renal insufficiency characterized by renal interstitial fibrosis. The induced and non-induced PBMCs were transplanted, and the efficacy of iMSCs in treating chronic renal insufficiency was evaluated using a variety of methods. The ultimate goal was to explore the effects of iMSC transplantation on the treatment of chronic renal insufficiency, with the aim of providing a new therapeutic modality for this disease.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Fibrosis
/ Hypoxia
/ Induced Pluripotent Stem Cells - cytology
/ Induced Pluripotent Stem Cells - transplantation
/ Leukocytes, Mononuclear - cytology
/ Medicine and Health Sciences
/ Mesenchymal Stem Cell Transplantation
/ Mesenchymal Stromal Cells - cytology
/ Mesenchymal Stromal Cells - metabolism
/ Nanog Homeobox Protein - genetics
/ Nanog Homeobox Protein - metabolism
/ Octamer Transcription Factor-3 - genetics
/ Octamer Transcription Factor-3 - metabolism
/ Rabbits
/ Renal Insufficiency, Chronic - etiology
/ Renal Insufficiency, Chronic - pathology
/ Renal Insufficiency, Chronic - therapy
/ Research and Analysis Methods
/ Studies
/ Transforming Growth Factor beta1 - metabolism
