Journal Article

Effects of blood glucose level on 18F-FDG uptake for PET/CT in normal organs: A systematic review

Watte, Guilherme, Irion, Klaus, Altmayer, Stephan, Hochhegger, Bruno, Sprinz, Clarice, Zanon, Matheus, Marchiori, Edson

2018

Overview

To perform a systematic review of the effect of blood glucose levels on 2-Deoxy-2-[18F]fluoro-D-glucose (18F-FDG) uptake in normal organs. We searched the MEDLINE, EMBASE and Cochrane databases through 22 April 2017 to identify all relevant studies using the keywords \"PET/CT\" (positron emission tomography/computed tomography), \"standardized uptake value\" (SUV), \"glycemia,\" and \"normal.\" Analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Maximum and mean SUVs and glycemia were the main parameters analyzed. To objectively measure the magnitude of the association between glycemia and 18F-FDG uptake in different organs, we calculated the effect size (ES) and the coefficient of determination (R2) whenever possible. The literature search yielded 225 results, and 14 articles met the inclusion criteria; studies included a total of 2714 (range, 51-557) participants. The brain SUV was related significantly and inversely to glycemia (ES = 1.26; R2 0.16-0.58). Although the liver and mediastinal blood pool were significantly affected by glycemia, the magnitudes of these associations were small (ES = 0.24-0.59, R2 = 0.01-0.08) and negligible (R2 = 0.02), respectively. Lung, bone marrow, tumor, spleen, fat, bowel, and stomach 18F-FDG uptakes were not influenced by glycemia. Individual factors other than glycemia can also affect 18F-FDG uptake in different organs, and body mass index appears to be the most important of these factors. The impact of glycemia on SUVs in most organs is either negligible or too small to be clinically significant. The brain SUV was the only value largely affected by glycemia.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Biological Transport / Biology and Life Sciences / Blood / Blood glucose / Blood Glucose - analysis / Body mass / Body mass index / Body size / Bone marrow / Brain / Brain - diagnostic imaging / Brain - drug effects / Brain - metabolism / Brain research / Breast cancer / Computed tomography / Contrast media (Chemicals) / Diabetes / Diagnostic imaging / Emission analysis / Fasting / Fluorine isotopes / Fluorodeoxyglucose F18 - pharmacokinetics / Glucose / Health sciences / Humans / Hyperglycemia / Intestine / Literature reviews / Liver / Lungs / Mathematical analysis / Medical imaging / Medicine and Health Sciences / Metabolism / Methods / Nuclear medicine / Observations / Organs / Patients / Physiological regulation / Positron emission / Positron emission tomography / Positron Emission Tomography Computed Tomography - methods / Properties / Quality / Radiopharmaceuticals - pharmacokinetics / Research and Analysis Methods / Spleen / Stomach / Studies / Systematic review