Journal Article

Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization

Olasińska-Wiśniewska, Anna, Misterski, Marcin, Urbanowicz, Tomasz, Michalak, Michał, Rodzki, Michał, Jemielity, Marek, Al-Imam, Ahmed, Straburzyńska-Migaj, Ewa, Lesiak, Maciej, Witkowska, Anna, Bociański, Michał, Perek, Bartłomiej

2022

Overview

Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59–64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) >1.27 (HR = 6.16, 95% CI 2.17–17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p<0.001).

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Biology and Life Sciences / Blood platelets / Blood tests / Cardiovascular disease / Care and treatment / Chronic obstructive pulmonary disease / Clinical medicine / Coronary artery bypass / Coronary Artery Bypass - methods / Coronary Artery Bypass, Off-Pump - methods / Coronary artery disease / Coronary Artery Disease - surgery / Coronary heart disease / Coronary vessels / Diagnosis / Ejection fraction / Heart diseases / Humans / Inflammation / Inflammatory response / Laboratories / Low density lipoprotein / Lymphocytes / Medical prognosis / Medicine and Health Sciences / Middle Aged / Mortality / Myocardial revascularization / Neutrophils / Patient outcomes / Patients / Population studies / Prognosis / Retrospective Studies / Statistical analysis / Stroke / Surgery / Survival / Survival Rate / Systemic Inflammatory Response Syndrome - etiology / Treatment Outcome / Vein & artery diseases