Journal Article

Diabetes-free survival among living kidney donors and non-donors with obesity: A longitudinal cohort study

Locke, Jayme E., Kumar, Vineeta, Pittman, Sydney E., Baker, Gavin A., McLeod, M. Chandler, Killian, A. Cozette, Stanford, Luke A., Reed, Rhiannon D., Schinstock, Carrie A., Silkensen, John R., MacLennan, Paul A., Orandi, Babak J., Segev, Dorry L., Lewis, Cora E., Roll, Garrett R., Maynor, Andrew G.

2022

Overview

Approval of living kidney donors (LKD) with end-stage kidney disease (ESKD) risk factors, such as obesity, has increased. While lifetime ESKD development data are lacking, the study of intermediate outcomes such as diabetes is critical for LKD safety. Donation-attributable diabetes risk among persons with obesity remains unknown. The purpose of this study was to evaluate 10-year diabetes-free survival among LKDs and non-donors with obesity. This longitudinal cohort study identified adult, LKDs (1976-2020) from 42 US transplant centers and non-donors from the Coronary Artery Risk Development in Young Adults (1985-1986) and the Atherosclerosis Risk in Communities (1987-1989) studies with body mass index ≥30 kg/m2. LKDs were matched to non-donors on baseline characteristics (age, sex, race, body mass index, systolic and diastolic blood pressure) plus diabetes-specific risk factors (family history of diabetes, impaired fasting glucose, smoking history). Accelerated failure time models were utilized to evaluate 10-year diabetes-free survival. Among 3464 participants, 1119 (32%) were LKDs and 2345 (68%) were non-donors. After matching on baseline characteristics plus diabetes-specific risk factors, 4% (7/165) LKDs and 9% (15/165) non-donors developed diabetes (median follow-up time 8.5 (IQR: 5.6-10.0) and 9.1 (IQR: 5.9-10.0) years, respectively). While not significant, LKDs were estimated to live diabetes-free 2 times longer than non-donors (estimate 1.91; 95% CI: 0.79-4.64, p = 0.15). LKDs with obesity trended toward living longer diabetes-free than non-donors with obesity, suggesting within the decade following donation there was no increased diabetes risk among LKDs. Further work is needed to evaluate donation-attributable diabetes risk long-term.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Arteriosclerosis / Atherosclerosis / Biology and Life Sciences / Blood pressure / Body mass / Body mass index / Body size / Cohort analysis / Cohort Studies / Complications and side effects / Consent / Coronary artery / Diabetes / Diabetes mellitus / Diabetes Mellitus - etiology / End-stage renal disease / Failure times / Family medical history / Genetics / Gestational diabetes / Glucose / Health aspects / Health risks / Humans / Insulin / Kidney diseases / Kidney Failure, Chronic / Kidney Transplantation - adverse effects / Kidney transplants / Kidneys / Living Donors / Longitudinal Studies / Medical records / Medicine and Health Sciences / Metabolism / Nephrectomy / Obesity / Obesity - complications / Obesity - epidemiology / Organ donors / Patient outcomes / Physical Sciences / Risk analysis / Risk factors / Self report / Statistics / Survival / Transplantation / Young Adult / Young adults