Journal Article

Patterns of brain atrophy in recently-diagnosed relapsing-remitting multiple sclerosis

York, Elizabeth N., Hunt, David P. J., Kampaite, Agniete, Waldman, Adam D., Harris, Mathew A., Meijboom, Rozanna, Thrippleton, Michael J., Chandran, Siddharthan, Valdés Hernández, Maria del C., Connick, Peter, White, Nicole, MacDougall, N. J. J.

2023

Overview

Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to neurodegeneration, resulting in progressive disability. Repeated magnetic resonance imaging (MRI) of the brain provides non-invasive measures of atrophy over time, a key marker of neurodegeneration. This study investigates regional neurodegeneration of the brain in recently-diagnosed RRMS using volumetry and voxel-based morphometry (VBM). RRMS patients (N = 354) underwent 3T structural MRI <6 months after diagnosis and 1-year follow-up, as part of the Scottish multicentre ‘FutureMS’ study. MRI data were processed using FreeSurfer to derive volumetrics, and FSL for VBM (grey matter (GM) only), to establish regional patterns of change in GM and normal-appearing white matter (NAWM) over time throughout the brain. Volumetric analyses showed a decrease over time (q<0.05) in bilateral cortical GM and NAWM, cerebellar GM, brainstem, amygdala, basal ganglia, hippocampus, accumbens, thalamus and ventral diencephalon. Additionally, NAWM and GM volume decreased respectively in the following cortical regions, frontal: 14 out of 26 regions and 16/26; temporal: 18/18 and 15/18; parietal: 14/14 and 11/14; occipital: 7/8 and 8/8. Left GM and NAWM asymmetry was observed in the frontal lobe. GM VBM analysis showed three major clusters of decrease over time: 1) temporal and subcortical areas, 2) cerebellum, 3) anterior cingulum and supplementary motor cortex; and four smaller clusters within the occipital lobe. Widespread GM and NAWM atrophy was observed in this large recently-diagnosed RRMS cohort, particularly in the brainstem, cerebellar GM, and subcortical and occipital-temporal regions; indicative of neurodegeneration across tissue types, and in accord with limited previous studies in early disease. Volumetric and VBM results emphasise different features of longitudinal lobar and loco-regional change, however identify consistent atrophy patterns across individuals. Atrophy measures targeted to specific brain regions may provide improved markers of neurodegeneration, and potential future imaging stratifiers and endpoints for clinical decision making and therapeutic trials.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Amygdala / Analysis / Atrophy / Atrophy - pathology / Basal ganglia / Biology and Life Sciences / Biomarkers / Brain / Brain - diagnostic imaging / Brain - pathology / Brain research / Brain stem / Central Nervous System Diseases - pathology / Cerebellum / Cingulum / Clinical trials / Clusters / Complications and side effects / Cortex (motor) / Decision making / Development and progression / Diagnosis / Diagnostic imaging / Diencephalon / Frontal lobe / Ganglia / Gray Matter - diagnostic imaging / Gray Matter - pathology / Humans / Inflammation / Magnetic resonance / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Medical imaging / Medical imaging equipment / Medical research / Medicine and Health Sciences / Medicine, Experimental / Morphometry / Multiple sclerosis / Multiple Sclerosis - pathology / Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging / Multiple Sclerosis, Relapsing-Remitting - pathology / Neurodegeneration / Neuroimaging / Nucleus accumbens / Occipital lobe / Research and Analysis Methods / Statistical analysis / Substantia alba / Substantia grisea / Temporal cortex / Temporal lobe / Thalamus