Asset Details
Do you wish to reserve the book?
Oligodendrocytes support axonal transport and maintenance via exosome secretion
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Oligodendrocytes support axonal transport and maintenance via exosome secretion
Do you wish to request the book?
Oligodendrocytes support axonal transport and maintenance via exosome secretion
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Oligodendrocytes support axonal transport and maintenance via exosome secretion
2020
Overview
Neurons extend long axons that require maintenance and are susceptible to degeneration. Long-term integrity of axons depends on intrinsic mechanisms including axonal transport and extrinsic support from adjacent glial cells. The mechanisms of support provided by myelinating oligodendrocytes to underlying axons are only partly understood. Oligodendrocytes release extracellular vesicles (EVs) with properties of exosomes, which upon delivery to neurons improve neuronal viability in vitro. Here, we show that oligodendroglial exosome secretion is impaired in 2 mouse mutants exhibiting secondary axonal degeneration due to oligodendrocyte-specific gene defects. Wild-type oligodendroglial exosomes support neurons by improving the metabolic state and promoting axonal transport in nutrient-deprived neurons. Mutant oligodendrocytes release fewer exosomes, which share a common signature of underrepresented proteins. Notably, mutant exosomes lack the ability to support nutrient-deprived neurons and to promote axonal transport. Together, these findings indicate that glia-to-neuron exosome transfer promotes neuronal long-term maintenance by facilitating axonal transport, providing a novel mechanistic link between myelin diseases and secondary loss of axonal integrity.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Axonal Transport - physiology
/ Axons
/ Brain-derived neurotrophic factor
/ Differential thermal analysis
/ Exosomes
/ Extracellular Vesicles - metabolism
/ Extracellular Vesicles - physiology
/ Female
/ Humans
/ Male
/ Medicine and Health Sciences
/ Mice
/ Myelin
/ Myelin-associated glycoprotein
/ Neurons
/ Oligodendroglia - metabolism
/ Oligodendroglia - physiology
/ Proteins
/ Research and Analysis Methods
/ Signal Transduction - physiology
/ Size exclusion chromatography
/ Transmission electron microscopy
/ Vesicles
We currently cannot retrieve any items related to this title. Kindly check back at a later time.