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Evidence for postnatal neurogenesis in the human amygdala

by Schwab, Stefan , Rost, Fabian , Rode, Julian , Roeder, Sebastian S. , Håkansson, Karl , Burkardt, Petra , Coras, Roland , Possnert, Göran , Tonchev, Anton B. , Molnár, Sarolta , Huttner, Hagen B. , Salehpour, Mehran , Méhes, Gábor , Primetzhofer, Daniel , Englund, Elisabet , Csiba, László , Bergmann, Olaf , Brusch, Lutz

in 13 / 14 / 631/378/2611 / 631/378/368/2431 / Amygdala / Amygdala - physiology / Animals / Basic Medicine / Biology / Biomedical and Life Sciences / Dating / Decision making / Genomic analysis / Hippocampus - physiology / Humans / Life Sciences / Lipofuscin / Mammals / Mass spectroscopy / Mathematical models / Medical and Health Sciences / Medicin och hälsovetenskap / Medicinska och farmaceutiska grundvetenskaper / Neurogenesis / Neurogenesis - physiology / Neurosciences / Neurovetenskaper / Retrospective Studies

2022

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2022

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2022

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Journal Article

Evidence for postnatal neurogenesis in the human amygdala

Schwab, Stefan,

Rost, Fabian,

Rode, Julian,

Roeder, Sebastian S.,

Håkansson, Karl,

Burkardt, Petra,

Coras, Roland,

Possnert, Göran,

Tonchev, Anton B.,

Molnár, Sarolta,

Huttner, Hagen B.,

Salehpour, Mehran,

Méhes, Gábor,

Primetzhofer, Daniel,

Englund, Elisabet,

Csiba, László,

Bergmann, Olaf,

Brusch, Lutz

2022

Overview

The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and 14 C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenesis exists in the human amygdala. We investigated post-mortem samples of twelve neurologically healthy subjects. The average rate of lipofuscin-negative neurons was 3.4%, representing a substantial proportion of cells substantially younger than the individual. Mass spectrometry analysis of genomic 14 C-concentrations in amygdala neurons compared with atmospheric 14 C-levels provided evidence for postnatal neuronal exchange. Mathematical modelling identified a best-fitting scenario comprising of a quiescent and a renewing neuronal population with an overall renewal rate of >2.7% per year. In conclusion, we provide evidence for postnatal neurogenesis in the human amygdala with cell turnover rates comparable to the hippocampus. Lipofuscin labeling and 14 C retrospective birth-dating of neurons, along with mathematical modelling, here suggest continued postnatal neurogenesis in the human amygdala, rather than protracted maturation of developmentally generated neurons.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 14

/ 631/378/2611

/ 631/378/368/2431

/ Amygdala

/ Amygdala - physiology

/ Animals

/ Basic Medicine