Journal Article

Sex-related differences in pre-dialysis trajectories and dialysis initiation: A French nationwide retrospective study

Couchoud, Cécile, Bourasseau, Louise, Bayat, Sahar, Vigneau, Cécile, Glowacki, François, Raffray, Maxime, Béchade, Clémence

2024

Overview

In the last two decades, sex and gender differences have been documented in chronic kidney disease (CKD) management, including access to renal replacement therapy and its outcomes. The objectives of this study were to 1) compare the pre-dialysis healthcare utilization in men and women, and 2) examine the sex-specific factors associated with emergency dialysis start. Adult patients with CKD who started dialysis in France in 2015 were extracted from the Renal Epidemiology and Information Network registry. Patients were matched to the French National Health Data System database to extract healthcare utilization data for the 2 years before dialysis start. Frequencies and monthly rates of consultations and hospitalizations were compared between men and women. Logistic regression analyses were performed separately in the two groups. Among the 8856 patients included, 3161 (35.7%) were women. Median age (71 years) and estimated glomerular filtration rate (8.1 and 7.7 ml/min for men and women) were similar between groups at dialysis start. Monthly consultations rates with a general practitioner and nephrology-related care were similar between women and men. Some sex-specific differences were found: higher frequencies of consultations with a psychiatrist in women and more frequent hospitalizations for circulatory system diseases in men. Emergency dialysis start rate was 30% in both groups. Emergency dialysis start was associated with acute nephropathy, compared with slowly progressive nephropathy, in women but not in men (OR = 1.48, p<0.01 vs 1.15, p = 0.18). This study found similar quantitative pre-dialysis healthcare utilization in men and women. To better understand sex/gender differences in CKD care trajectories, future research should focus on patients with CKD who are unknown to nephrology services, on patients receiving conservative care and on the sex/gender-specific mechanisms underlying care decision-making.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Analysis / Cardiovascular disease / Chronic kidney failure / Circulatory system / Creatinine / Data base management systems / Data systems / Decision making / Demographic aspects / Development and progression / Dialysis / Ecology, environment / Epidemiology / Evaluation / Gender / Gender aspects / Gender differences / Glomerular filtration rate / Health / Health care / Health services utilization / Hemodialysis / Hospitalization / Hospitals / Kidney diseases / Life Sciences / Medical research / Medicine and Health Sciences / Medicine, Experimental / Men / Methods / Nephrology / Nephropathy / Patients / People and places / Population / Regression analysis / Renal replacement therapy / Santé publique et épidémiologie / Sex / Sex differences / Transplants & implants / Utilization / Women / Womens health