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Crossover Patterning by the Beam-Film Model: Analysis and Implications
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Crossover Patterning by the Beam-Film Model: Analysis and Implications
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Journal Article
Crossover Patterning by the Beam-Film Model: Analysis and Implications
2014
Overview
Crossing-over is a central feature of meiosis. Meiotic crossover (CO) sites are spatially patterned along chromosomes. CO-designation at one position disfavors subsequent CO-designation(s) nearby, as described by the classical phenomenon of CO interference. If multiple designations occur, COs tend to be evenly spaced. We have previously proposed a mechanical model by which CO patterning could occur. The central feature of a mechanical mechanism is that communication along the chromosomes, as required for CO interference, can occur by redistribution of mechanical stress. Here we further explore the nature of the beam-film model, its ability to quantitatively explain CO patterns in detail in several organisms, and its implications for three important patterning-related phenomena: CO homeostasis, the fact that the level of zero-CO bivalents can be low (the \"obligatory CO\"), and the occurrence of non-interfering COs. Relationships to other models are discussed.
Publisher
Public Library of Science,Public Library of Science (PLoS)
