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Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study
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Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study
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Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study
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Journal Article
Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study
2016
Overview
Background
Many human studies report that nitric oxide (NO) improves sport performance. This is because NO is a potential modulator of blood flow, muscle energy metabolism, and mitochondrial respiration during exercise. L-Citrulline is an amino acid present in the body and is a potent endogenous precursor of L-arginine, which is a substrate for NO synthase. Here, we investigated the effect of oral L-citrulline supplementation on cycling time trial performance in humans.
Methods
A double-blind randomized placebo-controlled 2-way crossover study was employed. Twenty-two trained males consumed 2.4 g/day of L-citrulline or placebo orally for 7 days. On Day 8 they took 2.4 g of L-citrulline or placebo 1 h before a 4-km cycling time trial. Time taken to complete the 4 km cycle, along with power output/VO
2
ratio (PO/VO
2
), plasma nitrite and nitrate (NOx) and amino acid levels, and visual analog scale (VAS) scores, was evaluated.
Results
L-Citrulline supplementation significantly increased plasma L-arginine levels and reduced completion time by 1.5 % (
p
< 0.05) compared with placebo. Moreover, L-citrulline significantly improved subjective feelings of muscle fatigue and concentration immediately after exercise.
Conclusions
Oral L-citrulline supplementation reduced the time take to complete a cycle ergometer exercise trial.
Trial registration
Current Controlled Trials
UMIN000014278
.
Publisher
BioMed Central,BioMed Central Ltd,Taylor & Francis Ltd
Subject
/ Adult
/ arginine
/ Asian Continental Ancestry Group
/ Blood Pressure - drug effects
/ Citrulline - administration & dosage
/ Cycling
/ exercise
/ Exercise Tolerance - drug effects
/ Humans
/ Male
/ males
/ Medicine
/ men
/ Muscle, Skeletal - metabolism
/ muscles
/ nitrates
/ Nitric Oxide Synthase - drug effects
/ nitrites
/ Oxygen Consumption - drug effects
/ Performance-Enhancing Substances - administration & dosage
/ Performance-Enhancing Substances - blood
/ Performance-Enhancing Substances - pharmacology
/ placebos
