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Variation in genomic islands contribute to genome plasticity in Cupriavidus metallidurans
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Variation in genomic islands contribute to genome plasticity in Cupriavidus metallidurans
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Variation in genomic islands contribute to genome plasticity in Cupriavidus metallidurans
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Journal Article
Variation in genomic islands contribute to genome plasticity in Cupriavidus metallidurans
2012
Overview
Background
Different
Cupriavidus metallidurans
strains isolated from metal-contaminated and other anthropogenic environments were genotypically and phenotypically compared with
C. metallidurans
type strain CH34. The latter is well-studied for its resistance to a wide range of metals, which is carried for a substantial part by its two megaplasmids pMOL28 and pMOL30.
Results
Comparative genomic hybridization (CGH) indicated that the extensive arsenal of determinants involved in metal resistance was well conserved among the different
C. metallidurans
strains. Contrary, the mobile genetic elements identified in type strain CH34 were not present in all strains but clearly showed a pattern, although, not directly related to a particular biotope nor location (geographical). One group of strains carried almost all mobile genetic elements, while these were much less abundant in the second group. This occurrence was also reflected in their ability to degrade toluene and grow autotrophically on hydrogen gas and carbon dioxide, which are two traits linked to separate genomic islands of the Tn
4371
-family. In addition, the clear pattern of genomic islands distribution allowed to identify new putative genomic islands on chromosome 1 and 2 of
C. metallidurans
CH34.
Conclusions
Metal resistance determinants are shared by all
C. metallidurans
strains and their occurrence is apparently irrespective of the strain's isolation type and place.
Cupriavidus metallidurans
strains do display substantial differences in the diversity and size of their mobile gene pool, which may be extensive in some (including the type strain) while marginal in others.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Bacterial Proteins - genetics
/ Biomedical and Life Sciences
/ Cerebrospinal Fluid - microbiology
/ Chromium
/ DNA
/ Drug Resistance, Bacterial - genetics
/ Gene Transfer, Horizontal - genetics
/ Genome, Bacterial - genetics
/ Genomes
/ Genomics
/ Hydrogen
/ Islands
/ Metals
/ Microbial Genetics and Genomics
/ Oligonucleotide Array Sequence Analysis
/ Plasmids
/ Stress, Physiological - genetics
/ Toluene
