Asset Details
Do you wish to reserve the book?
Horizontal Transfer, Not Duplication, Drives the Expansion of Protein Families in Prokaryotes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Horizontal Transfer, Not Duplication, Drives the Expansion of Protein Families in Prokaryotes
Do you wish to request the book?
Horizontal Transfer, Not Duplication, Drives the Expansion of Protein Families in Prokaryotes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Horizontal Transfer, Not Duplication, Drives the Expansion of Protein Families in Prokaryotes
2011
Overview
Gene duplication followed by neo- or sub-functionalization deeply impacts the evolution of protein families and is regarded as the main source of adaptive functional novelty in eukaryotes. While there is ample evidence of adaptive gene duplication in prokaryotes, it is not clear whether duplication outweighs the contribution of horizontal gene transfer in the expansion of protein families. We analyzed closely related prokaryote strains or species with small genomes (Helicobacter, Neisseria, Streptococcus, Sulfolobus), average-sized genomes (Bacillus, Enterobacteriaceae), and large genomes (Pseudomonas, Bradyrhizobiaceae) to untangle the effects of duplication and horizontal transfer. After removing the effects of transposable elements and phages, we show that the vast majority of expansions of protein families are due to transfer, even among large genomes. Transferred genes--xenologs--persist longer in prokaryotic lineages possibly due to a higher/longer adaptive role. On the other hand, duplicated genes--paralogs--are expressed more, and, when persistent, they evolve slower. This suggests that gene transfer and gene duplication have very different roles in shaping the evolution of biological systems: transfer allows the acquisition of new functions and duplication leads to higher gene dosage. Accordingly, we show that paralogs share most protein-protein interactions and genetic regulators, whereas xenologs share very few of them. Prokaryotes invented most of life's biochemical diversity. Therefore, the study of the evolution of biology systems should explicitly account for the predominant role of horizontal gene transfer in the diversification of protein families.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Bradyrhizobiaceae - genetics
/ Computational Biology/Comparative Sequence Analysis
/ Computational Biology/Genomics
/ Computational Biology/Population Genetics
/ Enterobacteriaceae - genetics
/ Evolutionary Biology/Evolutionary and Comparative Genetics
/ Genes
/ Genetics
/ Genetics and Genomics/Genomics
/ Genetics and Genomics/Microbial Evolution and Genomics
/ Genomics
/ Proteins
We currently cannot retrieve any items related to this title. Kindly check back at a later time.