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HiGlass: web-based visual exploration and analysis of genome interaction maps

by Hwang, Jeewon , Strobelt, Hendrik , Abdennur, Nezar , Dinkla, Kasper , Lee, Soohyun , Park, Peter J. , Luber, Jacob M. , Kumar, Nikhil , Gehlenborg, Nils , Mirny, Leonid A. , Pfister, Hanspeter , Azhir, Alaleh , McCallum, Chuck , Ouellette, Scott B. , Kerpedjiev, Peter , Alver, Burak H. , Lekschas, Fritz

in Algorithms / Animal Genetics and Genomics / Bioinformatics / Biomedical and Life Sciences / Cell cycle / Chromosome conformation / Chromosome Mapping / Chromosomes / Data processing / Data visualization / Datasets / Evolutionary Biology / Exploration / Gene loci / Gene mapping / Genome / Genomes / Genomics / Hi-C / Human Genetics / Internet / Life Sciences / Microbial Genetics and Genomics / Plant Genetics and Genomics / Researchers / Software / User-Computer Interface / Visualization

2018

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2018

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2018

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Journal Article

HiGlass: web-based visual exploration and analysis of genome interaction maps

Hwang, Jeewon,

Strobelt, Hendrik,

Abdennur, Nezar,

Dinkla, Kasper,

Lee, Soohyun,

Park, Peter J.,

Luber, Jacob M.,

Kumar, Nikhil,

Gehlenborg, Nils,

Mirny, Leonid A.,

Pfister, Hanspeter,

Azhir, Alaleh,

McCallum, Chuck,

Ouellette, Scott B.,

Kerpedjiev, Peter,

Alver, Burak H.,

Lekschas, Fritz

2018

Overview

We present HiGlass, an open source visualization tool built on web technologies that provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps alongside 1D genomic tracks, allowing users to combine various data types, synchronize multiple visualization modalities, and share fully customizable views with others. We demonstrate its utility in exploring different experimental conditions, comparing the results of analyses, and creating interactive snapshots to share with collaborators and the broader public. HiGlass is accessible online at http://higlass.io and is also available as a containerized application that can be run on any platform.

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Publisher

BioMed Central,Springer Nature B.V,BMC

Subject

Algorithms

/ Animal Genetics and Genomics

/ Bioinformatics

/ Biomedical and Life Sciences

/ Cell cycle

/ Chromosome conformation

/ Chromosome Mapping