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A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
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Journal Article
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
2014
Overview
Richard Houlston and colleagues report results of a genome-wide association study of chronic lymphocytic leukemia. They validate several new susceptibility loci for this disease, including variants near
POT1
,
TERC
and
TERT
.
Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599,
P
= 1.74 × 10
−9
), 4q26 (rs6858698,
P
= 3.07 × 10
−9
), 6q25.2 (
IPCEF1
, rs2236256,
P
= 1.50 × 10
−10
) and 7q31.33 (
POT1
, rs17246404,
P
= 3.40 × 10
−8
). Additionally, we identified a promising association at 5p15.33 (
CLPTM1L
, rs31490,
P
= 1.72 × 10
−7
) and validated recently reported putative associations at 5p15.33 (
TERT
, rs10069690,
P
= 1.12 × 10
−10
) and 8q22.3 (rs2511714,
P
= 2.90 × 10
−9
). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 38/77
/ 45/43
/ Aged
/ Analysis
/ Animal Genetics and Genomics
/ Chronic lymphocytic leukemia
/ DNA
/ Genetic Predisposition to Disease
/ Genome-Wide Association Study
/ Genomes
/ Humans
/ letter
/ Leukemia
/ Leukemia, Lymphocytic, Chronic, B-Cell - genetics
/ Lymphoma
/ Male
/ Medicinska och farmaceutiska grundvetenskaper
/ Membrane Proteins - genetics
/ Neoplasm Proteins - genetics
