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Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

by Kidd, J. R. , Watson, E. , Jenkins, T. , Risch, N. , Moral, P. , Speed, W. , Pääbo, S. , Tishkoff, S. A. , Santachiara-Benerecetti, A. S. , Cheung, K. , Pakstis, A. J. , Bonné-Tamir, B. , Kidd, K. K. , Dietzsch, E. , Krings, M.

in Africa / Alleles / Animals / Base Sequence / Biological and medical sciences / CD4 Antigens - genetics / Chromosomes / Chromosomes, Human, Pair 12 / Evolution / Evolution, Molecular / Fundamental and applied biological sciences. Psychology / Gene Frequency / Genetic drift / Genetic loci / Genetic mutation / Genetic Variation / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Haplotypes / Hominidae - genetics / Human / Human evolution / Human geography / Human populations / Humans / Linkage Disequilibrium / Molecular Sequence Data / Polymorphism, Genetic / Population / Population genetics, reproduction patterns / Population geography / Primates - genetics / Repetitive Sequences, Nucleic Acid / Sequence Deletion

1996

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Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

1996

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Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

1996

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Journal Article

Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

Kidd, J. R.,

Watson, E.,

Jenkins, T.,

Risch, N.,

Moral, P.,

Speed, W.,

Pääbo, S.,

Tishkoff, S. A.,

Santachiara-Benerecetti, A. S.,

Cheung, K.,

Pakstis, A. J.,

Bonné-Tamir, B.,

Kidd, K. K.,

Dietzsch, E.,

Krings, M.

1996

Overview

Haplotypes consisting of alleles at a short tandem repeat polymorphism (STRP) and an Alu deletion polymorphism at the CD4 locus on chromosome 12 were analyzed in more than 1600 individuals sampled from 42 geographically dispersed populations (13 African, 2 Middle Eastern, 7 European, 9 Asian, 3 Pacific, and 8 Amerindian). Sub-Saharan African populations had more haplotypes and exhibited more variability in frequencies of haplotypes than the Northeast African or non-African populations. The Alu deletion was nearly always associated with a single STRP allele in non-African and Northeast African populations but was associated with a wide range of STRP alleles in the sub-Saharan African populations. This global pattern of haplotype variation and linkage disequilibrium suggests a common and recent African origin for all non-African human populations.

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Publisher

American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Africa

/ Alleles

/ Animals

/ Base Sequence

/ Biological and medical sciences

/ CD4 Antigens - genetics

/ Chromosomes

/ Chromosomes, Human, Pair 12

/ Evolution

/ Evolution, Molecular

/ Fundamental and applied biological sciences. Psychology