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Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells
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Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells
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Journal Article
Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells
2017
Overview
Human induced pluripotent stem cells (hiPSCs) may provide potential resource for regenerative medicine research, including generation of insulin-producing cells for diabetes research and insulin production. Testosterone (T) is an androgen hormone which promotes protein synthesis and improves the management of type 2 diabetes in clinical studies. Concurrently, co-existed hyperandrogenism and hyperinsulinism is frequently observed in polycystic ovary syndrome, congenital adrenal hyperplasia and some of Wermer's syndrome. However, the relationship among androgens, insulin and the differentiation of pancreatic β cells is still not fully clear. Here we find that T improves the differentiation efficiency of insulin-producing cells from hiPSCs. The addition of T into routine differentiation formula for pancreatic β cells increases the differentiation efficiency from 12% to 35%. The administration of T promotes the expression of key genes associated with β cells differentiation including NGN3, NEUROD1 and INS. This finding benefits the ongoing process to optimize the differentiation protocol of pancreatic β cells from hiPSCs, and provides some degree of understanding the clinical management of T for type 2 diabetes.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Biology
/ Cell Differentiation - drug effects
/ Diabetes
/ Gene Expression Regulation - drug effects
/ Genes
/ Growth
/ Humans
/ Induced Pluripotent Stem Cells - cytology
/ Induced Pluripotent Stem Cells - drug effects
/ Induced Pluripotent Stem Cells - metabolism
/ Insulin
/ Insulin-Secreting Cells - cytology
/ Insulin-Secreting Cells - drug effects
/ Insulin-Secreting Cells - metabolism
/ Male
/ Medicine
/ Medicine and Health Sciences
/ Multiple Endocrine Neoplasia Type 1 - metabolism
/ Multiple Endocrine Neoplasia Type 1 - pathology
/ Pancreas
/ Research and Analysis Methods
/ Urine
