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DNA-Replikationsstress, Mitose und genomische Instabilität
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DNA-Replikationsstress, Mitose und genomische Instabilität
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Journal Article
DNA-Replikationsstress, Mitose und genomische Instabilität
2021
Overview
Chromosomal instability (CIN) is a hallmark of cancer and contributes to tumorigenesis and tumor progression. While structural CIN (S-CIN) leads to structural chromosome aberrations, whole chromosome instability (W-CIN) is defined by perpetual gains or losses of chromosomes during mitosis causing aneuploidy. Mitotic defects, but also abnormal DNA replication (replication stress) can lead to W-CIN. However, the functional link between replication stress, mitosis and aneuploidy is little understood.
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