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Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity
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Journal Article
Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity
1994
Overview
Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine the extent of their contribution to T cell-mediated cytotoxicity, a range of effector cells from normal control or perforin-deficient mice were tested against a panel of target cells with various levels of Fas expression. All cytotoxicity observed was due to either of these mechanisms, and no third mechanism was detected. Thus, the perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science
Subject
/ Animals
/ Antigens, Surface - immunology
/ Biological and medical sciences
/ Concanavalin A - pharmacology
/ Fundamental and applied biological sciences. Psychology
/ Immunological reactions in vitro
/ Lymphocyte Culture Test, Mixed
/ Lymphocytic choriomeningitis virus - immunology
/ Membrane Glycoproteins - immunology
/ Mice
/ Mixed lymphocyte culture test
/ Perforin
/ Pore Forming Cytotoxic Proteins
/ T cells
/ T-Lymphocytes, Cytotoxic - immunology
/ Tetradecanoylphorbol Acetate - pharmacology
/ Tumors
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