Journal Article

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

Davey Smith, George, Relton, Caroline L.

2010

Overview

  Abbreviations: CAD, coronary artery disease; CpG, cytosine guanine dinucleotide; DNMT, DNA methyltransferase; HDAC, histone deacetylase; HNSCC, head and neck squamous cell carcinoma; LDL-C, low density lipoprotein-cholesterol; microRNA, miRNA; SNP, single nucleotide polymorphism Provenance: Commissioned; externally peer reviewed. Epigenetic variation, whether genetically or environmentally determined, contributes to inter-individual variation in gene expression and thus to variation in common complex disease risk. * Interventions based upon epigenetic agents, including DNA methyltransferase inhibitors and histone deacetylase inhibitors, have been in clinical use for many years, but their role outside treatment of specific cancers is not established. * Epigenetic therapies will only be fruitful if epigenetic mechanisms are causally related to the disease being treated.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Deoxyribonucleic acid / Disease / DNA / DNA methylation / Epidemiologic methods / Epidemiology / Epigenesis, Genetic - physiology / Epigenetics / Genetics and Genomics / Genetics and Genomics/Epigenetics / Genomics / Health aspects / Humans / Metagenomics - methods / Models, Biological / Molecular Epidemiology / Preventive Medicine - methods / Prognosis / Rare Diseases - diagnosis / Rare Diseases - epidemiology / Rare Diseases - genetics / Rare Diseases - therapy / Research in Translation / Therapeutics - methods / Translational Research, Biomedical - methods / Translational Research, Biomedical - trends