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PatWRKY71 transcription factor regulates patchoulol biosynthesis and plant defense response
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Journal Article
PatWRKY71 transcription factor regulates patchoulol biosynthesis and plant defense response
2024
Overview
Patchoulol, a valuable compound belonging to the sesquiterpenoid family, is the primary component of patchouli oil produced by
Pogostemon cablin
(
P. cablin
). It has a variety of pharmacological and biological activities and is widely used in the medical and cosmetic industries. However, despite its significance, there is a lack of research on the transcriptional modulation of patchoulol biosynthesis.
Salicylic acid (SA), is a vital plant hormone that serves as a critical signal molecule and plays an essential role in plant growth and defense. However, to date, no studies have explored the modulation of patchoulol biosynthesis by SA. In our study, we discovered that the application of SA can enhance the production of patchoulol. Utilizing transcriptome analysis of SA-treated
P. cablin
, we identified a crucial downstream transcription factor, PatWRKY71. The transcription level of
PatWRKY71
was significantly increased with the use of SA. Furthermore, our research has revealed that PatWRKY71 was capable of binding to the promoter of
PatPTS
, ultimately leading to an increase in its expression. When
PatWRKY71
was silenced by a virus, the expression of both
PatWRKY71
and
PatPTS
was reduced, resulting in the down-regulation of patchoulol production. Through our studies, we discovered that heterologous expression of
PatWRKY71
leads to an increase in the sensitivity of
Arabidopsis
to salt and Cd, as well as an outbreak of reactive oxygen species (ROS). Additionally, we uncovered the regulatory role of
PatWRKY71
in both patchoulol biosynthesis and plant defense response. This discovery provided a theoretical basis for the improvement of the content of patchoulol and the resistance of
P. cablin
through genetic engineering.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Biomedical and Life Sciences
/ Cloning
/ Control
/ family
/ Genes
/ Genetically modified organisms
/ heterologous gene expression
/ Identification and classification
/ Leaves
/ Methods
/ oils
/ Traditional Chinese medicine
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ viruses
