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重组人白细胞介素-4对人肺腺癌细胞SPC-A1/TAX化疗增敏研究
by
林安华 李羲
in
MDR
/ rhIL-4
/ TAX
/ 上升趋势
/ 严重
/ 临床
/ 产生机制
/ 人肺腺癌细胞SPC-A1
/ 化疗增敏
/ 化疗失败
/ 化疗药物
/ 发病率
/ 可替代
/ 敏感性
/ 死亡率
/ 癌细胞分化
/ 白细胞介素-4
/ 细胞多药耐药性
/ 综合治疗
/ 肺癌
/ 肿瘤细胞
/ 逆转方法
/ 重组人
/ 针对性
2005
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重组人白细胞介素-4对人肺腺癌细胞SPC-A1/TAX化疗增敏研究
by
林安华 李羲
in
MDR
/ rhIL-4
/ TAX
/ 上升趋势
/ 严重
/ 临床
/ 产生机制
/ 人肺腺癌细胞SPC-A1
/ 化疗增敏
/ 化疗失败
/ 化疗药物
/ 发病率
/ 可替代
/ 敏感性
/ 死亡率
/ 癌细胞分化
/ 白细胞介素-4
/ 细胞多药耐药性
/ 综合治疗
/ 肺癌
/ 肿瘤细胞
/ 逆转方法
/ 重组人
/ 针对性
2005
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Journal Article
重组人白细胞介素-4对人肺腺癌细胞SPC-A1/TAX化疗增敏研究
2005
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Overview
近年来肺癌的发病率和死亡率呈明显上升趋势,严重威胁着人民的健康。在肺癌的综合治疗中,化疗起着不可替代的作用,然而,肺癌细胞多药耐药性(MDR)的产生,严重制约了肺癌化疗的效果,是引起肺癌化疗失败的关键因素。肺癌细胞多药耐药性是目前临床难以克服的课题之一,研究其产生机制并进一步寻求逆转方法,从而选择有针对性的化疗药物是临床迫切需要的。近年研究表明,rhIL-4能诱导癌细胞分化,增加某些肿瘤细胞对化疗药物的敏感性,从而降低MDR。
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