Asset Details
Do you wish to reserve the book?
西咪替丁对急性照射小鼠存活率及造血系统改变的影响
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
西咪替丁对急性照射小鼠存活率及造血系统改变的影响
Do you wish to request the book?
西咪替丁对急性照射小鼠存活率及造血系统改变的影响
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
西咪替丁对急性照射小鼠存活率及造血系统改变的影响
2017
Overview
目的观察西咪替丁对急性照射小鼠存活率及造血系统改变的影响。方法采用137Csγ射线全身照射小鼠,两次实验的照射剂量分别为6.0Gy和8.0Gy,剂量率均为1.01Gy/min。每次实验取健康雄性C57BL/6小鼠60只,按体重随机分为空白对照组、模型对照组、阳性药组（523）及33.3、100、300mg/kg西咪替丁组,每组10只。西咪替丁各剂量组于照射前6d灌胃给药,每天1次,照射后5h给药1次;阳性药组于照射前1d灌胃给药1次,照射后5h给药1次。检测8.0Gy照射后30d小鼠存活率,以及6.0Gy照射后30d小鼠外周血象、骨髓DNA含量和骨髓嗜多染红细胞微核率。结果8.0Gy照射后,模型对照组小鼠于第21天全部死亡,西咪替丁低、中、高剂量组30d存活率分别为50%、20%和30%;6.0Gy照射后第30天,与空白对照组比较,各照射组小鼠外周血白细胞明显降低（P〈0.01）,骨髓嗜多染红细胞微核率明显升高（P〈0.05）,骨髓DNA含量明显降低（P〈0.05）;与模型对照组比较,西咪替丁高剂量组外周血白细胞明显升高（P〈0.01）,西咪替丁各剂量组骨髓DNA含量明显升高（P〈0.01,P〈0.05）,而骨髓嗜多染红细胞微核率明显降低（P〈0.01,P〈0.05）并趋于正常。结论西咪替丁能提高急性照射小鼠30d存活率,且对其造血系统有较好的保护作用。
Publisher
People's Military Medical Press,200433,上海 海军医学研究所辐射防护效应研究室
Subject
