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肾移植受者术前甘油三酯代谢对移植肾早期功能恢复的影响
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肾移植受者术前甘油三酯代谢对移植肾早期功能恢复的影响
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Journal Article
肾移植受者术前甘油三酯代谢对移植肾早期功能恢复的影响
2017
Overview
目的 探讨肾移植受者术前甘油三酯（TG）代谢对其移植肾早期功能（EGF）恢复的影响。方法 回顾性分析2011年1月-2014年12月170例在解放军309医院接受活体肾移植受者的临床资料,经排除标准筛选后最终纳入154例受者,其中男124例,女30例,年龄31.9±8.4岁。根据受者术前TG水平分为TG正常组（0.401.70mmol/L或需服用降脂药控制血脂者,n=47）,观察两组患者中移植肾功能恢复不佳（PEGF）、肾功能延迟恢复（DGF）和肾功能缓慢恢复（SGF）的发生率,进一步比较移植肾功能顺利恢复（IGF）的两组受者术后3、7及30d的肌酐（Scr）水平。绘制以TG为诊断指标的ROC曲线,以获得预测肾移植术后发生PEGF、SGF、DGF风险的最佳TG值。结果 与TG正常组相比,TG异常组的受者术后PEGF及DGF的发病率较高,差异有统计学意义（P〈0.05）。IGF的受者中,TG异常组术后7、30d的Scr值高于TG正常组,差异有统计学意义（P〈0.05）。术前TG预测PEGF、SGF及DGF的ROC曲线下面积（AUC）分别为0.774、0.704、0.818,均明显大于机会参考下面积（P〈0.05）,最佳临界值均为1.37mmol/L。结论 受者术前TG代谢异常对移植肾早期功能恢复可能具有负性影响。术前受者TG在正常高值时（〉1.37mmol/L）,其发生PEGF、SGF和DGF的风险便已增加。
Publisher
People's Military Medical Press,100853 北京 解放军总医院研究生管理大队,461131 河南许昌 解放军61491部队%100091,北京 解放军309医院器官移植研究所泌尿外科
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