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人脐带间充质干细胞对大鼠重症急性胰腺炎的保护作用
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Journal Article
人脐带间充质干细胞对大鼠重症急性胰腺炎的保护作用
2017
Overview
目的 研究人脐带间充质干细胞（ucMSCs）对大鼠重症急性胰腺炎（SAP）的保护作用。方法 135只雄性SD大鼠随机分成对照组（Sham组）,SAP组和SAP＋ucMSCs组,每组45只。采用5%牛磺胆酸钠（0.1ml/100g）逆行胰管注射的方法制作大鼠SAP模型,SAP＋ucMSCs组通过尾静脉注射CM-Di I标记的ucMSCs（1×10^7个/kg）。各组于术后12、24、72h处死取材,统计大鼠死亡率,HE染色观察各组胰腺组织病理学改变并评分,荧光显微镜观察ucMSCs定植情况,ELISA法测定大鼠血清淀粉酶和脂肪酶、肿瘤坏死因子α（TNF-α）、白介素1β（IL-1β）、白介素4（IL-4）和白介素10（IL-10）的表达情况。结果 ucMSCs可定植在胰腺组织的损伤区域,可降低72h SAP大鼠的死亡率（SAP组为66.7%,SAP＋ucMSCs组为20.0%）。ucMSCs移植后大鼠各时间点血清淀粉酶和脂肪酶水平明显降低（P〈0.01）,胰腺组织病理学评分、炎性因子TNF-α、IL-1β水平明显降低,抗炎因子IL-4、IL-10水平明显升高（P〈0.05或P〈0.01）。结论 人脐带间充质干细胞移植治疗可减轻重症急性胰腺炎的胰腺组织损伤和炎症程度。
Publisher
People's Military Medical Press,610083 成都 成都军区总医院全军普外中心%610083,成都 成都军区总医院全军普外中心%611130,成都 成都康景生物科技有限公司,400038 重庆 第三军医大学研究生管理大队
Subject
