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Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease
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Journal Article
Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease
2009
Overview
The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Bile
/ Biomarkers, Tumor - metabolism
/ Chemistry/Physical, Inorganic, and Analytical Chemistry
/ Dermatologi och venerologi, klinisk genetik, invärtesmedicin
/ Dermatology and venerology,clinical genetics, internal medicine
/ Etiology
/ Feces
/ Gastroenterology and Hepatology/Inflammatory Bowel Disease
/ Genetics
/ Genomes
/ Humans
/ MEDICIN
/ MEDICINE
/ Microbiology/Applied Microbiology
/ Microbiota (Symbiotic organisms)
/ NMR
