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The Minimal Gene Complement of Mycoplasma genitalium

by Phillips, Cheryl A. , Venter, J. Craig , Lucier, Thomas S. , Nguyen, David , Kerlavage, Anthony R. , Fritchman, Janice L. , Gocayne, Jeannine D. , Sutton, Granger , Utterback, Teresa R. , Small, Keith V. , Weidman, Janice F. , Peterson, Scott N. , Bult, Carol J. , White, Owen , Hu, Ping-Chuan , Dougherty, Brian A. , Clayton, Rebecca A. , Merrick, Joseph M. , Sandusky, Mina , Fraser, Claire M. , Kelley, Jenny M. , Tomb, Jean-Francois , Hutchison, Clyde A. , Saudek, Deborah M. , Bott, Kenneth F. , Smith, Hamilton O. , Adams, Mark D. , Fleischmann, Robert D. , Furhmann, Joyce

in Amino acids / Antigenic Variation - genetics / Bacterial Proteins - genetics / Bacteriology / Biological and medical sciences / Biological Transport - genetics / Biosynthesis / Databases, Factual / DNA / DNA Repair - genetics / DNA Replication - genetics / DNA, Bacterial - genetics / Energy metabolism / Energy Metabolism - genetics / Fundamental and applied biological sciences. Psychology / Genes / Genes, Bacterial / Genetic aspects / Genetics / Genome, Bacterial / Genomes / Haemophilus influenzae / Haemophilus influenzae - genetics / Hemophilus influenzae / Microbiology / Molecular Sequence Data / Mollicutes / Mycoplasma - genetics / Mycoplasma - immunology / Mycoplasma - metabolism / Mycoplasma genitalium / Mycoplasmatales / Open Reading Frames / Operons / Protein Biosynthesis / Sequence Analysis, DNA / Sperm transport / Transcription, Genetic / Transfer RNA

1995

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The Minimal Gene Complement of Mycoplasma genitalium

1995

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1995

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Journal Article

The Minimal Gene Complement of Mycoplasma genitalium

Phillips, Cheryl A.,

Venter, J. Craig,

Lucier, Thomas S.,

Nguyen, David,

Kerlavage, Anthony R.,

Fritchman, Janice L.,

Gocayne, Jeannine D.,

Sutton, Granger,

Utterback, Teresa R.,

Small, Keith V.,

Weidman, Janice F.,

Peterson, Scott N.,

Bult, Carol J.,

White, Owen,

Hu, Ping-Chuan,

Dougherty, Brian A.,

Clayton, Rebecca A.,

Merrick, Joseph M.,

Sandusky, Mina,

Fraser, Claire M.,

Kelley, Jenny M.,

Tomb, Jean-Francois,

Hutchison, Clyde A.,

Saudek, Deborah M.,

Bott, Kenneth F.,

Smith, Hamilton O.,

Adams, Mark D.,

Fleischmann, Robert D.,

Furhmann, Joyce

1995

Overview

The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.

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Publisher

American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Amino acids

/ Antigenic Variation - genetics

/ Bacterial Proteins - genetics

/ Bacteriology

/ Biological and medical sciences

/ Biological Transport - genetics

/ Biosynthesis

/ Databases, Factual

/ DNA

/ DNA Repair - genetics

/ DNA Replication - genetics