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Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

by Khalak, Hanif , Weidman, Janice , Clayton, Rebecca , Venter, J. Craig , Fujii, Claire , Norris, Steven J. , Sutton, Granger G. , McDonald, Lisa , Cotton, Matthew D. , Roberts, Kevin , Bowman, Cheryl , Weinstock, George M. , Howell, Jerrilyn K. , White, Owen , Horst, Kurt , Artiach, Patricia , Sodergren, Erica , McLeod, Michael P. , Salzberg, Steven , Sandusky, Mina , Peterson, Jeremy , Fraser, Claire M. , Dodson, Robert , Hickey, Erin K. , Richardson, Delwood , Garland, Stacey , Hardham, John M. , Ketchum, Karen A. , Utterback, Teresa , Hatch, Bonnie , Smith, Hamilton O. , Gwinn, Michelle , Chidambaram, Monjula

in Amino acids / Bacteria / Bacterial Proteins - genetics / Bacterial Proteins - metabolism / Bacteriology / Base Sequence / Biological and medical sciences / Borrelia burgdorferi Group - genetics / Carrier Proteins - genetics / Carrier Proteins - metabolism / Causes and theories of causation / Chromosome mapping / Coding / Deoxyribonucleic acid / Diagnostic Tests / Diseases / DNA / DNA Repair - genetics / DNA Replication - genetics / DNA Restriction Enzymes - genetics / Energy Metabolism - genetics / Enzymes / Etiology (Medicine) / Fundamental and applied biological sciences. Psychology / Genes / Genes, Bacterial / Genes, Regulator / Genetic aspects / Genetics / Genome, Bacterial / Genomes / Heat-Shock Response - genetics / Lipoproteins - genetics / Lyme disease / Medical research / Membrane Proteins - genetics / Microbiology / Molecular Sequence Data / Movement / Open Reading Frames / Oxygen Consumption - genetics / Protein Biosynthesis / Proteins / Recombination, Genetic / Replication Origin / Research Article / Sequence Analysis, DNA / Sexually transmitted diseases / Spirochaetales / STD / Syphilis / Transcription, Genetic / Transfer RNA / Translation / Treponema pallidum / Treponema pallidum - genetics / Treponema pallidum - metabolism / Treponema pallidum - pathogenicity / Vector-borne diseases

1998

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Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

1998

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Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

1998

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Journal Article

Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

Khalak, Hanif,

Weidman, Janice,

Clayton, Rebecca,

Venter, J. Craig,

Fujii, Claire,

Norris, Steven J.,

Sutton, Granger G.,

McDonald, Lisa,

Cotton, Matthew D.,

Roberts, Kevin,

Bowman, Cheryl,

Weinstock, George M.,

Howell, Jerrilyn K.,

White, Owen,

Horst, Kurt,

Artiach, Patricia,

Sodergren, Erica,

McLeod, Michael P.,

Salzberg, Steven,

Sandusky, Mina,

Peterson, Jeremy,

Fraser, Claire M.,

Dodson, Robert,

Hickey, Erin K.,

Richardson, Delwood,

Garland, Stacey,

Hardham, John M.,

Ketchum, Karen A.,

Utterback, Teresa,

Hatch, Bonnie,

Smith, Hamilton O.,

Gwinn, Michelle,

Chidambaram, Monjula

1998

Overview

The complete genome sequence of Treponema pallidum was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phosphoenolpyruvate: phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.

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Publisher

American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Amino acids

/ Bacteria

/ Bacterial Proteins - genetics

/ Bacterial Proteins - metabolism

/ Bacteriology

/ Base Sequence

/ Biological and medical sciences

/ Borrelia burgdorferi Group - genetics

/ Carrier Proteins - genetics

/ Carrier Proteins - metabolism

/ Causes and theories of causation