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G Protein-Coupled Receptors in Anopheles gambiae

by Robertson, Hugh M. , Zwiebel, Laurence J. , Fox, A. Nicole , Chrystal, Mathew A. , Kent, Lauren B. , Collins, Frank H. , Cravchik, Anibal , Tan, Perciliz L. , Pitts, R. Jason , Hill, Catherine A.

in Algorithms / Alternative Splicing / Amino Acid Sequence / Amino acids / Animals / Anopheles / Anopheles - chemistry / Anopheles - genetics / Anopheles - metabolism / Anopheles gambiae / binding proteins / Biological taxonomies / chemistry / chemoreceptors / Computational Biology / Conserved Sequence / Culicidae / Drosophila melanogaster / Drosophila melanogaster - chemistry / Drosophila melanogaster - genetics / Drosophila melanogaster - metabolism / Drosophila Proteins / Drosophila Proteins - chemistry / Drosophila Proteins - genetics / Drosophila Proteins - metabolism / Evolution, Molecular / Family (Sociological Unit) / Freshwater / Gene Amplification / Gene Expression / genes / Genes, Insect / Genetic aspects / genetics / Genome / Genomes / Genomics / GTP-Binding Proteins / GTP-Binding Proteins - metabolism / guanosine triphosphate / Insect Proteins / Insect Proteins - chemistry / Insect Proteins - genetics / Insect Proteins - metabolism / interspecific variation / Life cycles / Ligands / Malaria / metabolism / Molecular Sequence Data / Mosquitoes / Mosquitos / Multigene Family / Neurons / odorant receptors / olfactory organs / Opsins / Orphans / Phylogeny / Proteins / Receptors / Receptors, Cell Surface / Receptors, Cell Surface - chemistry / Receptors, Cell Surface - genetics / Receptors, Cell Surface - metabolism / Receptors, Odorant / Receptors, Odorant - chemistry / Receptors, Odorant - genetics / Receptors, Odorant - metabolism / Reverse Transcriptase Polymerase Chain Reaction / Signal Transduction

2002

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G Protein-Coupled Receptors in Anopheles gambiae

by Robertson, Hugh M. , Zwiebel, Laurence J. , Fox, A. Nicole , Chrystal, Mathew A. , Kent, Lauren B. , Collins, Frank H. , Cravchik, Anibal , Tan, Perciliz L. , Pitts, R. Jason , Hill, Catherine A.

2002

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G Protein-Coupled Receptors in Anopheles gambiae

by Robertson, Hugh M. , Zwiebel, Laurence J. , Fox, A. Nicole , Chrystal, Mathew A. , Kent, Lauren B. , Collins, Frank H. , Cravchik, Anibal , Tan, Perciliz L. , Pitts, R. Jason , Hill, Catherine A.

2002

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Journal Article

G Protein-Coupled Receptors in Anopheles gambiae

Robertson, Hugh M.,

Zwiebel, Laurence J.,

Fox, A. Nicole,

Chrystal, Mathew A.,

Kent, Lauren B.,

Collins, Frank H.,

Cravchik, Anibal,

Tan, Perciliz L.,

Pitts, R. Jason,

Hill, Catherine A.

2002

Overview

We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Algorithms

/ Alternative Splicing

/ Amino Acid Sequence

/ Amino acids

/ Animals

/ Anopheles

/ Anopheles - chemistry