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Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate
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Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate
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Journal Article
Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate
2005
Overview
Instead of the immunoglobulin-type antigen receptors of jawed vertebrates, jawless fish have variable lymphocyte receptors (VLRs), which consist of leucine-rich repeat (LRR) modules. Somatic diversification of the VLR gene is shown here to occur through a multistep assembly of LRR modules randomly selected from a large bank of flanking cassettes. The predicted concave surface of the VLR is lined with hypervariable positively selected residues, and computational analysis suggests a repertoire of about 10¹⁴ unique receptors. Lamprey immunized with anthrax spores responded with the production of soluble antigen-specific VLRs. These findings reveal that two strikingly different modes of antigen recognition through rearranged lymphocyte receptors have evolved in the jawless and jawed vertebrates.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Analysis
/ Animals
/ Anthrax
/ Antigens
/ Bacillus anthracis - immunology
/ Bacillus subtilis - immunology
/ Biological and medical sciences
/ Cell structures and functions
/ Coding
/ fish
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Molecular and cellular biology
/ Receptors, Immunologic - genetics
/ Receptors, Immunologic - immunology
/ Spores
/ Spores, Bacterial - immunology
