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ДИСФУНКЦИЯ ЭНДОТЕЛИЯ ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ: ФАКТОРЫ РИСКА, МЕТОДЫ ДИАГНОСТИКИ И КОРРЕКЦИИ

by Vorobyev, R I , Batanina, I A , Sharlaeva, E A , Kazizaeva, A S , Vorobyeva, E N , Fomicheva, M L , Sokolova, G G

in Arteriosclerosis / Bradykinin / Cardiovascular disease / Cell proliferation / Circulatory system / Endothelins / Endothelium / Hemostasis / Nitric oxide / Prostacyclin / Risk factors / Smooth muscle / Thromboxane A2 / Vasoactive agents / Vasoconstrictors / Vasodilators / дисфункция эндотелия / оксид азота / сердечно-сосудистые заболевания / факторы риска / эндотелин

2016

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ДИСФУНКЦИЯ ЭНДОТЕЛИЯ ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ: ФАКТОРЫ РИСКА, МЕТОДЫ ДИАГНОСТИКИ И КОРРЕКЦИИ

by Vorobyev, R I , Batanina, I A , Sharlaeva, E A , Kazizaeva, A S , Vorobyeva, E N , Fomicheva, M L , Sokolova, G G

2016

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ДИСФУНКЦИЯ ЭНДОТЕЛИЯ ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ: ФАКТОРЫ РИСКА, МЕТОДЫ ДИАГНОСТИКИ И КОРРЕКЦИИ

by Vorobyev, R I , Batanina, I A , Sharlaeva, E A , Kazizaeva, A S , Vorobyeva, E N , Fomicheva, M L , Sokolova, G G

2016

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Journal Article

ДИСФУНКЦИЯ ЭНДОТЕЛИЯ ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ: ФАКТОРЫ РИСКА, МЕТОДЫ ДИАГНОСТИКИ И КОРРЕКЦИИ

Vorobyev, R I,

Batanina, I A,

Sharlaeva, E A,

Kazizaeva, A S,

Vorobyeva, E N,

Fomicheva, M L,

Sokolova, G G

2016

Overview

The endothelium plays a crucial role in regulating vascular tone, proliferation and migration of smooth muscle cells, and it maintains a balance of profibrinolytic and prothrombotic activity. These effects are mediated by the releasing of vasoactive substances. The main endothelium-derived vasodilators include nitric oxide, prostacyclin and bradykinin. These substances also regulates the local processes of a hemostasis and suppresses the smooth muscle cell growth. The vasoconstrictors, such as endothelin, thromboxane A2 and a ngiotensin I I contribute to the a therogenesis. The imbalance of endothelium-derived relaxing and contracting factors is defined as endothelium dysfunction. A number of conditions recognized as risk factors of atherosclerosis result to endothelial dysfunction by that or otherwise. So is actual to asses the indexes of endothelial function in men with risk factors of a therosclerosis before appearance of clinical signs of disease and assigning of pathogenetic therapy at this stage that will allow to improve the prognosis of patients.

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Publisher

Altai State University

Subject

Arteriosclerosis

/ Bradykinin

/ Cardiovascular disease