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三种竹鼠源致病性细菌混合感染病例的组织病理学变化分析
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Journal Article
三种竹鼠源致病性细菌混合感染病例的组织病理学变化分析
2021
Overview
实验旨在研究竹鼠混合感染致病性大肠杆菌、致病性棒状杆菌和致病性绿色气球菌所引起的组织病理学变化。通过剖检、组织切片、苏木素—伊红（HE）染色及图像观察分析法观察混合感染3种致病性细菌的组织器官的病理及组织病理学变化。结果显示：患病竹鼠下牙脱落，被毛杂乱无光泽，后发现心包有严重无色透明液体、心脏质地柔软凹陷、可见淤血，肝脏表面光滑分布红色细血丝、有明显出血点，肺脏表面可见深红色斑块；脾脏颜色较为暗沉、表面不粗糙、边缘呈锯齿状、肾脏呈大理石色，表面凹凸不平等；心肌细胞胞质疏松淡染肥大细胞浸润；肝索结构不清，肝细胞淀粉样变，呈嗜酸性均质状汇管区周围胆管增生，炎性细胞浸润；脾小结数量减少，红髓淋巴细胞减少，并可见大面积淀粉样变，呈嗜酸性均质状，髓窦可见淤血及出血。肺脏肺泡壁明显增厚，肺泡出血；肾脏肾小管上皮细胞空泡变性，胞质内可见微小空泡肾小管扩张，形状不规则，肾小球内可见炎性细胞浸润，少量肾小球萎缩，肾小囊内充满嗜酸性蛋白液等病理变化。本研究对混合感染致病性大肠杆菌、致病性棒状杆菌和致病性绿色气球菌的竹鼠病例组织进行了组织病理学观察和分析，以期为竹鼠细菌病的研究提供病理学参考资料。
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