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Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment
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Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment
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Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment
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Journal Article
Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment
2023
Overview
Fullerenes are a class of carbon nanomaterials that find a wide range of applications in biomedical fields, especially for photodynamic cancer therapy because of its photosensitive effect. However, hydrophobic fullerenes can only be dispersed in organic solvents which hinders their biomedical applications. Here, we report a facile method to prepare highly water‐dispersible fullerene (C60)‐polymer nanoparticles with hydrodynamic sizes of 50–70 nm. Hydrophilic random copolymers containing different ratios of polyethylene glycol methyl ether methacrylate and 2‐aminoethylmethacrylamide were synthesized for conjugating with C60 molecules through efficient nucleophilic Michael addition reaction between amine groups from hydrophilic polymer and carbon‐carbon double bonds from C60. As a result, the amphiphilic C60‐polymer conjugates could be well dispersed and nano‐assembled in water with a C60 concentration as high as 7.8 mg/mL, demonstrating a significant improvement for the solubility of C60 in an aqueous system. Owing to the high C60 content, the C60‐polymer nanoparticles showed a strong photodynamic therapy effect on human lung cancer cells (A549) under light irradiation (450 nm) in both 2D cell culture and 3D spheroid culture, while demonstrating ignorable cytotoxicity under dark. This highly efficient and convenient method to prepare water‐dispersible C60‐polymer conjugates may have a great impact on the future biomedical applications of fullerenes. This work used controlled living free radical polymerization (reversible addition‐fragmentation chain transfer) to prepare copolymers of precise compositions. The conjugation method of C60 molecules with polymers is more efficient and simpler to generate highly water‐dispersible nanoparticles compared to literature methods. In addition, the C60 concentration of this work is much higher than literature reported, yet the stability of nanoparticle aqueous solution is superior, which can be stored at room temperature for more than 1 year without aggregation. Such highly aqueously stable C60 nanoparticles showed non‐cytotoxicity under dark conditions but high photo‐cytotoxicity with light irradiation (visible light, short time and low intensity), which can lead to targeted killing of cancer cells.
