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The syntenic long non-coding RNA DANCR is an essential regulator of zebrafish development and a human melanoma oncogene
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The syntenic long non-coding RNA DANCR is an essential regulator of zebrafish development and a human melanoma oncogene
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Journal Article
The syntenic long non-coding RNA DANCR is an essential regulator of zebrafish development and a human melanoma oncogene
2025
Overview
Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression. Some are essential for organismal development and physiology, and they can contribute to diseases including cancer. Whilst most lncRNAs exhibit little sequence similarity, conservation of lncRNA transcription relative to neighbouring protein-coding genes suggests potential functional significance. Most positionally equivalent lncRNAs are uncharacterized and it remains unclear whether they exert similar roles in distant species. Here, we identified melanoma-associated lncRNAs predicted to be components of the MITF gene regulatory network in human melanoma that have positionally equivalent transcripts in zebrafish. We prioritized the cancer-associated lncRNA Differentiation Antagonizing Non-Protein Coding RNA (DANCR) as an exemplar for functional investigation. DANCR is a multi-exonic, cytoplasmically-enriched lncRNA and small RNA host gene transcribed from syntenic regions in the human and zebrafish genomes. MITF and c-MYC, key melanoma transcription factors, regulate human DANCR expression and melanoma patients with high DANCR display significantly decreased survival. DANCR is a melanoma oncogene that controls cancer-associated gene expression networks to promote human melanoma cell proliferation and migration. Zebrafish dancr is essential for embryonic development. It is dynamically expressed across multiple different cell types in the developing embryo, transcriptionally activated by mitfa during early zebrafish development and it regulates genes involved in cell death. Our work suggests that cancer-critical lncRNAs such as DANCR, expressed from similar regions in vertebrate genomes, may control related genes and processes involved in both embryonic development and tumorigenesis across species.
Publisher
PLOS,Public Library of Science (PLoS)
Subject
/ Cell Proliferation - genetics
/ Embryonic Development - genetics
/ Gene Expression Regulation, Developmental
/ Gene Expression Regulation, Neoplastic
/ Humans
/ Medicine and Health Sciences
/ Microphthalmia-Associated Transcription Factor - genetics
/ Proto-Oncogene Proteins c-myc - genetics
/ Research and Analysis Methods
/ RNA, Long Noncoding - genetics
