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Influence of rs1292037 Genetic Variant on miR‐21 Gene Expression in Patients With Type 1 Diabetes Mellitus: A Case‐Control Study
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Influence of rs1292037 Genetic Variant on miR‐21 Gene Expression in Patients With Type 1 Diabetes Mellitus: A Case‐Control Study
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Influence of rs1292037 Genetic Variant on miR‐21 Gene Expression in Patients With Type 1 Diabetes Mellitus: A Case‐Control Study
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Journal Article
Influence of rs1292037 Genetic Variant on miR‐21 Gene Expression in Patients With Type 1 Diabetes Mellitus: A Case‐Control Study
2025
Overview
Background and Aims Alterations in the expression pattern of miRNAs seem to be linked with autoimmune diseases such as type 1 diabetes mellitus (T1DM). Regarding the importance of assessing this potential link, we aimed to evaluate the relationship between miR‐21 rs1292037 single‐nucleotide polymorphism (SNP) and T1DM susceptibility. Furthermore, we investigated the miR‐21 expression level in T1DM. Methods A total of 250 T1DM patients and 250 controls were genotyped using polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) and miR‐21 expression levels were assessed using real‐time PCR. Moreover, the potential targets of miR‐21 were investigated using different bioinformatics web servers. Results Our results showed that the T/C genotype and the C allele were more frequent in T1DM patients than in controls. Individuals carrying the T/C genotype in overdominant model were 2.74‐fold at a higher risk of T1DM (OR = 2.74; 95%CI, 1.78–4.27; p < 0.0001). In addition, miR‐21 expression was more than twofold higher in patients than in controls (p < 0.0001) and it was found to be significantly upregulated when carrying the T/C genotype. Regarding miR‐21 predicted target genes, its overexpression may be associated with beta cell death, diabetic nephropathy, inflammatory responses, impaired insulin production or secretion, and T‐cell cytotoxicity, which are important in the initiation and progression of T1DM. Conclusion Our results suggested that miR‐21 rs1292037 may confer genetic susceptibility to T1DM. Therefore, it seems that this genetic link should be further investigated to enhance diagnostic and therapeutic strategies in these patients.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
