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Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis

by Nseir, Saad , Buil, Jochem B , Vanderbeke, Lore , Dupont, Herve , Bruggemann, Roger J.M , Tamion, Fabienne , Dunbar, Albert , van der Spoel, Hans I , Rijnders, Bart J.A , Wauters, Joost , van Regenmortel, Niels , Reynders, Marijke , Maizel, Julien , Debavaye, Yves , Janssen, Nico A.F , Chouaki, Taieb , Lormans, Piet , Bouman, Catherine S.C , Verweij, Paul E , Jacobs, Cato , Bourgeois, Marc , Lagrou, Katrien , Schouten, Jeroen A , Nyga, Remy , van Dijk, Karin , van de Veerdonk, Frank L , Rutsaert, Lynn , Ergun, Mehmet , Feys, Simon , Costa, Damien , Sendid, Boualem , Altenburg, Josje

in Acquired immune deficiency syndrome / AIDS / Aspergillosis / Clinical outcomes / Cohort analysis / coronavirus disease / Coronaviruses / COVID-19 / Dispatch / Drug dosages / Epidemiology / Expedited / Fungal infections / Hospital patients / Intensive care / Intensive care units / Life Sciences / Mortality / Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis / Observational studies / Patient outcomes / Pulmonary aspergillosis / respiratory infections / Risk factors / SARS / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Statistics

2021

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Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis

2021

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Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis

2021

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Journal Article

Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis

Nseir, Saad,

Buil, Jochem B,

Vanderbeke, Lore,

Dupont, Herve,

Bruggemann, Roger J.M,

Tamion, Fabienne,

Dunbar, Albert,

van der Spoel, Hans I,

Rijnders, Bart J.A,

Wauters, Joost,

van Regenmortel, Niels,

Reynders, Marijke,

Maizel, Julien,

Debavaye, Yves,

Janssen, Nico A.F,

Chouaki, Taieb,

Lormans, Piet,

Bouman, Catherine S.C,

Verweij, Paul E,

Jacobs, Cato,

Bourgeois, Marc,

Lagrou, Katrien,

Schouten, Jeroen A,

Nyga, Remy,

van Dijk, Karin,

van de Veerdonk, Frank L,

Rutsaert, Lynn,

Ergun, Mehmet,

Feys, Simon,

Costa, Damien,

Sendid, Boualem,

Altenburg, Josje

2021

Overview

We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease–associated pulmonary aspergillosis (CAPA). We found 10%–15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%–52%.

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Publisher

U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention

Subject

Acquired immune deficiency syndrome

/ AIDS

/ Aspergillosis

/ Clinical outcomes

/ Cohort analysis

/ coronavirus disease

/ Coronaviruses