Journal Article

Multidrug-Resistant Bacterial Colonization and Infections in Large Retrospective Cohort of Mechanically Ventilated COVID-19 Patients

Bottino, Nicola, Previtali, Paola, Santambrogio, Sara, Zuglian, Gianluca, Guerrero, Fernando A, Muscatello, Antonio, Marotta, Manuela, Monti, Gianpaola, Fior, Gabriele, Tardini, Francesca, Breda, Giuseppe, Bandera, Alessandra, Bolis, Matteo, Chatenoud, Liliane, Mangioni, Davide, Palomba, Emanuele, Chiaruttini, Maria V, Colombo, Jacopo, Fumagalli, Roberto, Stocchetti, Nino, Grasselli, Giacomo, Matinato, Caterina, Massobrio, Giovanni, Gori, Andrea

2023

Overview

Few data are available on incidence of multidrug-resistant organism (MDRO) colonization and infections in mechanically ventilated patients, particularly during the COVID-19 pandemic. We retrospectively evaluated all patients admitted to the COVID-19 intensive care unit (ICU) of Hub Hospital in Milan, Italy, during October 2020‒May 2021. Microbiologic surveillance was standardized with active screening at admission and weekly during ICU stay. Of 435 patients, 88 (20.2%) had MDROs isolated ≤48 h after admission. Of the remaining patients, MDRO colonization was diagnosed in 173 (51.2%), MDRO infections in 95 (28.1%), and non-MDRO infections in 212 (62.7%). Non-MDRO infections occurred earlier than MDRO infections (6 days vs. 10 days; p<0.001). Previous exposure to antimicrobial drugs within the ICU was higher in MDRO patients than in non-MDRO patients (116/197 [58.9%] vs. 18/140 [12.9%]; p<0.001). Our findings might serve as warnings for future respiratory viral pandemics and call for increased measures of antimicrobial stewardship and infection control.

• Publisher: U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention
• Subject: antimicrobial resistance / Artificial respiration / bacteria / Bacterial infections / Colonization / Complications and side effects / COVID-19 / Disease prevention / Drug resistance / Drug resistance in microorganisms / Emergency medical care / Health aspects / Hospital patients / Hospitals / Infection / Infectious diseases / Intensive care / MDR / Methicillin / multidrug resistant / Multidrug resistant organisms / multidrug-resistant bacteria / Multidrug-Resistant Bacterial Colonization and Infections in Large Retrospective Cohort of Mechanically Ventilated COVID-19 Patients / multidrug-resistant organism / Nosocomial infections / Pandemics / Patient safety / Risk factors / Sepsis / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Statistics / Ventilators