Journal Article

Perfluorohexyloctane Ophthalmic Solution (Miebo) for Dry Eye

Lishnak, Timothy, MD, Nigro, Stefanie C., PharmD, BCACP

2025

Overview

Drug Dosage Dose form Cost* Perfluorohexyloctane ophthalmic solution (Miebo) One drop in the affected eye 4 times per day Ophthalmic solution, 3-mL bottle $850 *—Estimated retail price of 1 month of treatment. No drug-drug interactions have been identified to date.1 TOLERABILITY Perfluorohexyloctane ophthalmic solution is well tolerated, and its safety profile is consistent with long-term use up to 1 year.4 As with saline, about 1% to 3% of patients using the solution will experience blurred vision and conjunctival redness.1 Discontinuation rates were comparable with those of saline.4 EFFECTIVENESS Perfluorohexyloctane ophthalmic solution has been evaluated in two studies of more than 1,200 patients with dry eye. Participants who switched from saline to perfluorohexyloctane ophthalmic solution in the extension study had improved visual analog scale scores as early as week 4, which were sustained for the remainder of the study.4 Perfluorohexyloctane ophthalmic solution has not yet been studied in head-to-head trials with other treatments.

• Publisher: American Academy of Family Physicians
• Subject: Contact lenses / Drug dosages / Eye diseases / Family Medicine/General Medicine / Internal Medicine / Ophthalmology / Pharmacists