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Hydrochlorothiazide vs. Chlorthalidone for the Treatment of Hypertension
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Hydrochlorothiazide vs. Chlorthalidone for the Treatment of Hypertension
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Journal Article
Hydrochlorothiazide vs. Chlorthalidone for the Treatment of Hypertension
2021
Overview
Evidence-Based Answer Chlorthalidone reduces systolic blood pressure (SBP) by 10 mm Hg more than hydrochlorothiazide at equal dosages (12.5 to 25 mg daily) in patients using monotherapy. Low-dose chlorthalidone (6.25 mg daily) and controlled-release hydrochlorothiazide (12.5 mg daily; not currently available in the United States) reduce 24-hour ambulatory SBP and diastolic blood pressure (DBP), whereas immediate-release hydrochlorothiazide (12.5 mg daily) may only reduce daytime SBP. A 2016 RCT (N = 54) evaluated the effect of low-dose chlorthalidone and hydrochlorothiazide on mean 24-hour ambulatory blood pressure.2 Patients were 18 to 65 years of age (mean = 45 years of age) with essential hypertension (SBP of 140 to 159 mm Hg, DBP of 90 to 99 mm Hg) and an average blood pressure of 148/93 mm Hg.
Publisher
American Academy of Family Physicians
