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Protection against filarial infection by 45–49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction
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Protection against filarial infection by 45–49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction
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Journal Article
Protection against filarial infection by 45–49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction
2015
Overview
Highlights • F8, F11 & F12 fractions of B. malayi adult worm extract stimulated NO release. • Immunization with F8 decreased parasite burden & upregulated NO, Th1 & Th2 cytokines. • Aminoguanidine treatment decreased NO release & enhanced worm load in immunized host. • Anti-IFN-γ abridged F8-mediated NO generation & iNOS expression at protein level. • 45–49 kDa F8 of B. malayi protects the host via IFN-γ mediated iNOS induction & may hold promise as vaccine source.
Subject
/ Animals
/ Antibodies, Helminth - blood
/ Antigens, Helminth - administration & dosage
/ Antigens, Helminth - chemistry
/ Antigens, Helminth - isolation & purification
/ Electrophoresis, Gel, Two-Dimensional
/ Electrophoresis, Polyacrylamide Gel
/ Enzyme Activators - administration & dosage
/ Enzyme Activators - chemistry
/ Enzyme Activators - isolation & purification
/ Interferon-gamma - secretion
/ Leukocytes, Mononuclear - immunology
/ Male
/ Murinae
/ Nitric Oxide Synthase Type II - metabolism
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/ Transforming Growth Factor beta - secretion
