Journal Article

Sec22b is a critical and non-redundant regulator of plasma cell maintenance

Bachelerie, Françoise, Balor, Stéphanie, Canales-Herrerias, Pablo, Alouche, Nagham, University of Sheffield [Sheffield], Alloatti, Andres, Linterman, Michelle A, Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM), Amigorena, Sebastian, Rahman, Nabila F, Balabanian, Karl, ANR-17-CE14-0019,OSTEOVALYMPH,Autocrinie et paracrinie de l'axe de signalisation CXCL12/CXCR4-CXCR7 dans la niche ostéo-vasculaire: impact sur la spécification et l'engagement lymphoïde des cellules souches hématopoïétiques, Stockholm, Daniel, Cardiff University, Taskiran, Hakan, Bonaud, Amélie, Soldan, Vanessa, Inflammation, microbiome, immunosurveillance (MI2) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Monash University [Melbourne], École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL), Peden, Andrew A, Immunité et cancer (U932) ; Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), The Babraha

2023

Overview

Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor (SNARE) Sec22b as a unique and critical regulator of plasma cell maintenance and function. In absence of Sec22b, plasma cells were hardly detectable and serum antibody titres were dramatically reduced. Accordingly, Sec22b deficient mice fail to mount a protective immune response. At the mechanistic level, we demonstrated that Sec22b contributes to efficient antibody secretion and is a central regulator of plasma cell maintenance through the regulation of their transcriptional identity and of the morphology of the endoplasmic reticulum and mitochondria. Altogether, our results unveil an essential and non-redundant role for Sec22b as a regulator of plasma cell fitness and of the humoral immune response.

• Publisher: National Academy of Sciences,CCSD
• Subject: Life Sciences
• ISBN: 0010452683000