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Potentiating the antitumour response of CD8.sup.+ T cells by modulating cholesterol metabolism

by Bai, Yibing , Meng, Xiangbo , Chang, Ta-Yuan , Xu, Chenguang , Chen, Shuokai , Wang, Jing , Zhou, Penghui , Yang, Wei , Wang, Lijuan , Zhang, Ti , Zhang, Jin , Song, Bao-Liang , Yan, Chengsong , Xiong, Ying , Li, Lunyi , Chang, Catharine C.Y , Zheng, Xiaojun

in Care and treatment / Cholesterol metabolism / Health aspects / T cells / Tumors

2016

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Potentiating the antitumour response of CD8.sup.+ T cells by modulating cholesterol metabolism

in Care and treatment / Cholesterol metabolism / Health aspects / T cells / Tumors

2016

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Potentiating the antitumour response of CD8.sup.+ T cells by modulating cholesterol metabolism

in Care and treatment / Cholesterol metabolism / Health aspects / T cells / Tumors

2016

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Journal Article

Potentiating the antitumour response of CD8.sup.+ T cells by modulating cholesterol metabolism

Bai, Yibing,

Meng, Xiangbo,

Chang, Ta-Yuan,

Xu, Chenguang,

Chen, Shuokai,

Wang, Jing,

Zhou, Penghui,

Yang, Wei,

Wang, Lijuan,

Zhang, Ti,

Zhang, Jin,

Song, Bao-Liang,

Yan, Chengsong,

Xiong, Ying,

Li, Lunyi,

Chang, Catharine C.Y,

Zheng, Xiaojun

2016

Overview

Modulating cholesterol metabolism can improve CD8.sup.+ T-cell-mediated immunity against tumours; genetic or pharmacological inhibition of the cholesterol esterification enzyme ACAT1 led to higher plasma membrane cholesterol levels, better T-cell receptor clustering and signalling, improved immunological synapse maturation, and enhanced antitumour activity in mice.

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Publisher

Nature Publishing Group

Subject

Care and treatment

/ Cholesterol metabolism

/ Health aspects

/ T cells

/ Tumors