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Blocking extracellular glycine uptake mediated by GlyTI mitigates protoporphyria
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Blocking extracellular glycine uptake mediated by GlyTI mitigates protoporphyria
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Journal Article
Blocking extracellular glycine uptake mediated by GlyTI mitigates protoporphyria
2025
Overview
Accumulation of the light-reactive heme precursor protoporphyrin IX (PPIX) in blood causes protoporphyria, a disease characterized by severe pain resulting from sunlight exposure, as well as by the occurrence of liver failure in some patients. Thus, decreasing PPIX biosynthesis is a promising strategy to treat protoporphyria. In this issue of the JCI, Ducamp et al. report that inhibition of the glycine plasma membrane transporter GLYT1 using bitopertin decreased PPIX accumulation and ameliorated liver disease using human in vitro and mouse in vivo models. Their findings support the ongoing development of bitopertin to treat protoporphyria, while concurrently pointing to underexplored roles of glycine in erythroid cells.
Publisher
American Society for Clinical Investigation
Subject
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