Asset Details
Do you wish to reserve the book?
A Short Peptide That Mimics the Binding Domain of TGF-beta1 Presents Potent Anti-Inflammatory Activity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A Short Peptide That Mimics the Binding Domain of TGF-beta1 Presents Potent Anti-Inflammatory Activity
Do you wish to request the book?
A Short Peptide That Mimics the Binding Domain of TGF-beta1 Presents Potent Anti-Inflammatory Activity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A Short Peptide That Mimics the Binding Domain of TGF-beta1 Presents Potent Anti-Inflammatory Activity
2015
Overview
The transforming growth factor beta 1 (TGF-[beta]1) is a pleiotropic cytokine with multiple roles in development, wound healing, and immune regulation. TGF-[beta]1-mediated immune dysfunction may lead to pathological conditions, such as inflammation. Chronic inflammatory process is characterized by a continuous release of pro-inflammatory cytokines, and the inhibition or the blockage of these cytokines signaling pathways are considered a target treatment. In this context, despite the high numbers of TGF-[beta]-targeted pathways, the inducible regulatory T cells (iTreg) to control inflammation seems to be a promising approach. Our aim was to develop novel peptides through phage display (PhD) technology that could mimic TGF-[beta]1 function with higher potency. Specific mimetic peptides were obtained through a PhD subtraction strategy from whole cell binding using TGF-[beta]1 recombinant as a competitor during elution step. We have selected a peptide that seems to play an important role on cellular differentiation and modulation of TNF-[alpha] and IL-10 cytokines. The synthetic pm26TGF-[beta]1 peptide tested in PBMC significantly down-modulated TNF-[alpha] and up-regulated IL-10 responses, leading to regulatory T cells (Treg) phenotype differentiation. Furthermore, the synthetic peptide was able to decrease leukocytes rolling in BALB/C mice and neutrophils migration during inflammatory process in C57BL/6 mice. These data suggest that this peptide may be useful for the treatment of inflammatory diseases, especially because it displays potent anti-inflammatory properties and do not exhibit neutrophils' chemoattraction.
Publisher
Public Library of Science
