Asset Details
Do you wish to reserve the book?
Gut-licensed IFNgamma.sup.+ NK cells drive LAMP1.sup.+TRAIL.sup.+ anti-inflammatory astrocytes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Gut-licensed IFNgamma.sup.+ NK cells drive LAMP1.sup.+TRAIL.sup.+ anti-inflammatory astrocytes
Do you wish to request the book?
Gut-licensed IFNgamma.sup.+ NK cells drive LAMP1.sup.+TRAIL.sup.+ anti-inflammatory astrocytes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Gut-licensed IFNgamma.sup.+ NK cells drive LAMP1.sup.+TRAIL.sup.+ anti-inflammatory astrocytes
2021
Overview
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions.sup.1. However, little is known about the homeostatic anti-inflammatory activities of astrocytes and their regulation. Here, using high-throughput flow cytometry screening, single-cell RNA sequencing and CRISPR-Cas9-based cell-specific in vivo genetic perturbations in mice, we identify a subset of astrocytes that expresses the lysosomal protein LAMP1.sup.2 and the death receptor ligand TRAIL.sup.3. LAMP1.sup.+TRAIL.sup.+ astrocytes limit inflammation in the CNS by inducing T cell apoptosis through TRAIL-DR5 signalling. In homeostatic conditions, the expression of TRAIL in astrocytes is driven by interferon-[gamma] (IFN[gamma]) produced by meningeal natural killer (NK) cells, in which IFN[gamma] expression is modulated by the gut microbiome. TRAIL expression in astrocytes is repressed by molecules produced by T cells and microglia in the context of inflammation. Altogether, we show that LAMP1.sup.+TRAIL.sup.+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFN[gamma].sup.+ NK cells that are licensed by the microbiome.
Publisher
Nature Publishing Group
Subject
