Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma

by Deng, J , Sun, C-Y , Yan, H , Tang, B , Ai, L-S , Chen, L , Chu, Z-B , Xu, J , Hu, Y , Wang, K , Zhang, L , Wu, Q-L , Wu, X-F

in 13/2 / 13/31 / 13/51 / 42/109 / 45/61 / 45/77 / 45/90 / 631/67/1990/804 / 64/60 / 82/1 / Angiogenesis / Apoptosis / Bone marrow / Cancer / Cancer Research / Carcinogenesis / Care and treatment / Cell cycle / Critical Care Medicine / Deoxyribonucleic acid / Deregulation / Development and progression / DNA / DNA Methylation / Epigenesis, Genetic / Epigenetics / Gene expression / Gene silencing / Genes / Genetic aspects / Genetic research / Growth factors / Health aspects / Hematology / Hospitals / Humans / INK4a protein / Intensive / Internal Medicine / Leukemia / Medicine / Medicine & Public Health / MicroRNAs / mRNA / Multiple myeloma / Multiple Myeloma - blood supply / Multiple Myeloma - genetics / Neovascularization / Neovascularization, Pathologic - genetics / Non-coding RNA / Oncology / Oncology, Experimental / original-article / p16 Protein / Pathogenesis / Patients / Plasma / Proteins / Reduction / Regulators / RNA / RNA, Small Interfering - genetics / Tumor cell lines / Tumor suppressor genes / Tumorigenesis / Tumorigenicity / Tumors / Vascular endothelial growth factor

2015

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma

by Deng, J , Sun, C-Y , Yan, H , Tang, B , Ai, L-S , Chen, L , Chu, Z-B , Xu, J , Hu, Y , Wang, K , Zhang, L , Wu, Q-L , Wu, X-F

2015

Confirm

Do you wish to request the book?

piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma

by Deng, J , Sun, C-Y , Yan, H , Tang, B , Ai, L-S , Chen, L , Chu, Z-B , Xu, J , Hu, Y , Wang, K , Zhang, L , Wu, Q-L , Wu, X-F

2015

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma

Deng, J,

Sun, C-Y,

Yan, H,

Tang, B,

Ai, L-S,

Chen, L,

Chu, Z-B,

Xu, J,

Hu, Y,

Wang, K,

Zhang, L,

Wu, Q-L,

Wu, X-F

2015

Overview

Aberrant DNA hypermethylation contributes to myelomagenesis by silencing tumor-suppressor genes. Recently, a few reports have suggested that a novel class of small non-coding RNAs, called Piwi-interacting RNAs (piRNAs), may be involved in the epigenetic regulation of cancer. In this study, for the first time we provided evidence that the expression of piRNA-823 was upregulated in multiple myeloma (MM) patients and cell lines, and positively correlated with clinical stage. Silencing piRNA-823 in MM cells induced deregulation of cell cycle regulators and apoptosis-related proteins expression, accompanied by inhibition of tumorigenicity in vitro and in vivo . Moreover, piRNA-823 was directly relevant to de novo DNA methyltransferases, DNMT3A and 3B, in primary CD138 + MM cells. The inhibited expression of piRNA-823 in MM cells resulted in marked reduction of DNMT3A and 3B at both mRNA and protein levels, which in turn led to decrease in global DNA methylation and reexpression of methylation-silenced tumor suppressor, p16 INK4A . In addition, piRNA-823 abrogation in MM cells induced reduction of vascular endothelial growth factor secretion, with consequent decreased proangiogenic activity. Altogether, these data support an oncogenic role of piRNA-823 in the biology of MM, providing a rational for the development of piRNA-targeted therapeutic strategies in MM.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

13/2

/ 13/31

/ 13/51

/ 42/109

/ 45/61

/ 45/77

/ 45/90