Asset Details
Do you wish to reserve the book?
Structure–Function Interplay in Piezoelectric PCL/BaTiOsub.3 Scaffolds Fabricated by Phase Separation: Correlation of Morphology, Mechanics, and Cytocompatibility
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Structure–Function Interplay in Piezoelectric PCL/BaTiOsub.3 Scaffolds Fabricated by Phase Separation: Correlation of Morphology, Mechanics, and Cytocompatibility
Do you wish to request the book?
Structure–Function Interplay in Piezoelectric PCL/BaTiOsub.3 Scaffolds Fabricated by Phase Separation: Correlation of Morphology, Mechanics, and Cytocompatibility
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Structure–Function Interplay in Piezoelectric PCL/BaTiOsub.3 Scaffolds Fabricated by Phase Separation: Correlation of Morphology, Mechanics, and Cytocompatibility
2026
Overview
Bone regeneration relies on the coordinated interplay between mechanical and biological cues. Piezoelectric composites, capable of converting mechanical strain into electrical signals, offer a promising approach to stimulate osteogenesis. This study aimed to develop and characterize polycaprolactone (PCL) and barium titanate (BaTiO[sub.3]) composite scaffolds fabricated through thermally induced phase separation (TIPS), and to systematically evaluate the effects of polymer concentration and ceramic incorporation on scaffold morphology, porosity, mechanical properties, and cytocompatibility were systematically evaluated. The resulting scaffolds exhibited a highly porous, interconnected architecture, with 9% PCL formulation showing the most uniform morphology and consistent mechanical and biological behavior. Incorporation of BaTiO[sub.3] did not alter pore structure or compromise cytocompatibility but slightly enhanced stiffness and surface uniformity. SEM-based image analysis confirmed homogeneous BaTiO[sub.3] dispersion across all formulations. MTT assays and confocal microscopy demonstrated robust pre-osteoblast adhesion and spreading, particularly on denser composite scaffolds, confirming that the inclusion of BaTiO[sub.3] supports a favorable environment for cell proliferation. Overall, optimizing polymer concentration and ceramic dispersion enables fabrication of structurally coherent, cytocompatible scaffolds. The findings establish structure–property–biology relationships that serve as a baseline for future investigations into the electromechanical behavior of PCL/BaTiO[sub.3] scaffolds and their potential to promote osteogenic differentiation under physiological loading.
Publisher
MDPI AG
Subject
