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Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents
Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents
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Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents
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Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents
Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents

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Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents
Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents
Journal Article

Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using IN/I-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents

2023
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Overview
A green one-pot 2,3,6-trifunctionalization of N-alkyl/aryl indoles was achieved by adding three equivalents of N-Br sulfoximine to the indole solution. A variety of 2-sulfoximidoyl-3,6-dibromo indoles were prepared with 38–94% yields using N-Br sulfoximines as both brominating and sulfoximinating reagents. Based on the results of controlled experiments, we propose that a radical substitution involving 3,6-dibromination and 2-sulfoximination occurs in the reaction process. This is first time that 2,3,6-trifunctionalization of indole in one pot has been achieved.
Publisher
MDPI AG