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Green Synthesis of Silver Nanoparticles Using IRandia aculeata/I L. Cell Culture Extracts, Characterization, and Evaluation of Antibacterial and Antiproliferative Activity
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Green Synthesis of Silver Nanoparticles Using IRandia aculeata/I L. Cell Culture Extracts, Characterization, and Evaluation of Antibacterial and Antiproliferative Activity
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Journal Article
Green Synthesis of Silver Nanoparticles Using IRandia aculeata/I L. Cell Culture Extracts, Characterization, and Evaluation of Antibacterial and Antiproliferative Activity
2022
Overview
The demand for metallic nanoparticles synthesized using green methods has increased due to their various therapeutic and clinical applications, and plant biotechnology may be a potential resource facilitating sustainable methods of AgNPs synthesis. In this study, we evaluate the capacity of extracts from Randia aculeata cell suspension culture (CSC) in the synthesis of AgNPs at different pH values, and their activity against pathogenic bacteria and cancer cells was evaluated. Using aqueous CSC extracts, AgNPs were synthesized with 10% (w/v) of fresh biomass and AgNO[sub.3] (1 mM) at a ratio of 1:1 for 24 h of incubation and constant agitation. UV-vis analysis showed a high concentration of AgNPs as the pH increased, and TEM analysis showed polydisperse nanoparticles with sizes from 10 to 90 nm. Moreover, CSC extracts produce reducing agents such as phenolic compounds (162.2 ± 27.9 mg gallic acid equivalent/100 g biomass) and flavonoids (122.07 ± 8.2 mg quercetin equivalent/100 g biomass). Notably, AgNPs had strong activity against E. coli, S. pyogenes, P. aeruginosa, S. aureus, and S. typhimurium, mainly with AgNPs at pH 6 (MIC: 1.6 to 3.9 µg/mL). AgNPs at pH 6 and 10 had a high antiproliferative effect on cancer cells (IC[sub.50] < 5.7 µg/mL). Therefore, the use of cell suspension cultures may be a sustainable option for the green synthesis of AgNPs.
Publisher
MDPI AG
Subject
