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Childhood Adiposity Associated With Expanded Effector Memory CD8.sup.+ and Vdelta2.sup.+Vgamma9.sup.+ T Cells
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Childhood Adiposity Associated With Expanded Effector Memory CD8.sup.+ and Vdelta2.sup.+Vgamma9.sup.+ T Cells
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Journal Article
Childhood Adiposity Associated With Expanded Effector Memory CD8.sup.+ and Vdelta2.sup.+Vgamma9.sup.+ T Cells
2021
Overview
Context: Adult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent in childhood. Objective: To study associations between child adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8, and [gamma][delta] T cell lineages. Methods: Ten-year-old children (n = 890) from the Generation R Cohort underwent dual-energy x-ray absorptiometry and magnetic resonance imaging for body composition (body mass index [BMI], fat mass index [FMI], android-to-gynoid fat mass ratio, visceral fat index, liver fat fraction). Blood samples were taken for detailed immunophenotyping of leukocytes by 11-color flow cytometry. Results: Several statistically significant associations were observed. A 1-SD increase in total FMI was associated with +8.4% (95% CI 2.0, 15.2) V[delta][2.sup.+]V[gamma][9.sup.+] and +7.4% (95% CI 2.4, 12.5) CD[8.sup.+.sup.TEMRO] cell numbers. A 1-SD increase in visceral fat index was associated with +10.7% (95% CI 3.3, 18.7) V[delta][2.sup.+]V[gamma][9.sup.+] and +8.3% (95% CI 2.6, 14.4) CD[8.sup.+.sup.TEMRO] cell numbers. Higher android-to-gynoid fat mass ratio was only associated with higher V[delta][2.sup.+]V[gamma][9.sup.+] T cells. Liver fat was associated with higher CD[8.sup.+.sup.TEMRO] cells but not with V[delta][2.sup.+]V[gamma][9.sup.+] T cells. Only liver fat was associated with lower Th17 cell numbers: a 1-SD increase was associated with -8.9% (95% CI -13.7, -3.7) Th17 cells. No associations for total CD[8.sup.+], CD[4.sup.+] T cells, or monocytes were observed. BMI was not associated with immune cells. Conclusion: Higher V[delta][2.sup.+]V[gamma][9.sup.+] and CD[8.sup.+.sup.EMRO] cell numbers in children with higher visceral fat index could reflect presence of adiposity-related inflammation in children with adiposity of a general population. Key Words: child, effector memory T cell, gamma delta T cell, fat mass, inflammation, monocyte
Publisher
Oxford University Press
Subject
