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Quercetin Suppresses Proliferation of Liver Cancer Cell Lines In Vitro
by
Ogasawara, Sachiko
, Akagi, Yoshito
, Fukutomi, Shogo
, Nakashima, Osamu
, Naito, Yoshiki
, Nomura, Yoriko
, Fujita, Fumihiko
, Tanigawa, Masahiko
, SAKAI, HISAMUNE
, Yano, Hirohisa
, Goto, Yuichi
, Akiba, Jun
, Nakashima, Kouta
, Okuda, Koji
, Sato, Toshihiro
, Mizobe, Tomoaki
, HISAKA, TORU
in
Apoptosis
/ Cell cycle
/ Cell growth
/ Cell proliferation
/ Cell viability
/ Cholangiocarcinoma
/ Flow cytometry
/ Hepatitis
/ Hepatocytes
/ Liver cancer
/ Quantitative analysis
/ Quercetin
/ Synergistic effect
/ Tumor cell lines
2020
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Quercetin Suppresses Proliferation of Liver Cancer Cell Lines In Vitro
by
Ogasawara, Sachiko
, Akagi, Yoshito
, Fukutomi, Shogo
, Nakashima, Osamu
, Naito, Yoshiki
, Nomura, Yoriko
, Fujita, Fumihiko
, Tanigawa, Masahiko
, SAKAI, HISAMUNE
, Yano, Hirohisa
, Goto, Yuichi
, Akiba, Jun
, Nakashima, Kouta
, Okuda, Koji
, Sato, Toshihiro
, Mizobe, Tomoaki
, HISAKA, TORU
in
Apoptosis
/ Cell cycle
/ Cell growth
/ Cell proliferation
/ Cell viability
/ Cholangiocarcinoma
/ Flow cytometry
/ Hepatitis
/ Hepatocytes
/ Liver cancer
/ Quantitative analysis
/ Quercetin
/ Synergistic effect
/ Tumor cell lines
2020
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Quercetin Suppresses Proliferation of Liver Cancer Cell Lines In Vitro
by
Ogasawara, Sachiko
, Akagi, Yoshito
, Fukutomi, Shogo
, Nakashima, Osamu
, Naito, Yoshiki
, Nomura, Yoriko
, Fujita, Fumihiko
, Tanigawa, Masahiko
, SAKAI, HISAMUNE
, Yano, Hirohisa
, Goto, Yuichi
, Akiba, Jun
, Nakashima, Kouta
, Okuda, Koji
, Sato, Toshihiro
, Mizobe, Tomoaki
, HISAKA, TORU
in
Apoptosis
/ Cell cycle
/ Cell growth
/ Cell proliferation
/ Cell viability
/ Cholangiocarcinoma
/ Flow cytometry
/ Hepatitis
/ Hepatocytes
/ Liver cancer
/ Quantitative analysis
/ Quercetin
/ Synergistic effect
/ Tumor cell lines
2020
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Quercetin Suppresses Proliferation of Liver Cancer Cell Lines In Vitro
Journal Article
Quercetin Suppresses Proliferation of Liver Cancer Cell Lines In Vitro
2020
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Overview
Background/Aim: We investigated the anti-proliferative effect of quercetin on liver cancer cell lines. Materials and Methods: Thirteen liver cancer cell lines were cultured followed by treatment with varying concentrations of quercetin (0-100 μM) or quercetin and 5-FU, and the cell viability was analysed by the MTT assay. Flow cytometry was also used to examine cell cycle progression after treatment with quercetin. Results: The addition of quercetin resulted in a dose- and time-dependent suppression of cell proliferation. In some cell lines, treatment with quercetin and 5-FU caused an additional or synergistic effect. Most cell lines displayed cell cycle arrest at different phases of the cell cycle. Conclusion: Quercetin inhibits the proliferation of liver cancer cells via induction of apoptosis and cell cycle arrest.
Publisher
International Institute of Anticancer Research
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